John Driver on Muck Rack

John Driver

Verified
Nashville
As seen in: Talk About That, Nature, Crosswalk.com, Daily Camera, Diabetes Magazine, Relevant Magazine, Christianity.com, Plough Quarterly Magazine, Craven Herald & Pioneer, Keighley News, iBelieve and
Husband. Dad. Writer. Minister. Podcaster. Very amateur runner. Coauthor of Not So Black and White 👇Start reading here👇 johndriver.com
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Articles

Why pigs might help us develop better vaccines and drugs against influenza virus

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By John Driver Verified, Daniela S. Rajao, Anika Singanayagam, Montserrat Torremorell, Elma Tchilian
| Nature Verified
Advances in genetic engineering, immunological tools, single-cell transcriptomics and in vivo imaging have strengthened the usefulness of pigs in influenza research. Alongside standardized challenge models and optimized transmission studies, the pig model is poised to have an even greater role in the development of next-generation influenza vaccines and therapeutics.
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Poor sleep impairs immune responses and influenza vaccine protection

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By Minhui Guan, Weihong Gu, Alex Gileles-Hillel, Abdelnaby Khalyfa, Pradeep Balamalaliyage, Wikanda Tunterak, Moran Li, Yi Huang, Yuhan Wen, John Driver Verified, David Gozal, Xiu-Feng Wan
| Nature Verified
Abstract Disrupted sleep is increasingly recognized as a factor influencing vaccine efficacy, yet the mechanisms by which sleep disruption affects vaccine-induced immunity remain incompletely understood. Sleep fragmentation, a hallmark of several common sleep disorders, may interfere with immune processes required for effective vaccination. Here, we show that chronic sleep fragmentation (CSF) markedly impairs immune responses to influenza vaccination.
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Epitope-spanning antigenic variation reprograms immunodominance and broadens immunity in sequential influenza vaccination - Nature Communications

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By Xiu-Feng Wan, Minhui Guan, Pradeep Balamalaliyage, Hanqiao Chen, Kritika Prasai, Ana P. Alcala, Ana C. Alcalá, John Driver Verified, Alicia K. Olivier, Weihong Gu, Cheng Gao, Chengcheng Wang, Tao Li, Wikanda Tunterak, Qiongying Yang, Ashwin Ramesh, Muzaffar Ali, David SMith, David Smith, Andrea J. Sant, jun hang, Hang Xie, Mingyi Zhou, Yizhi Jane Tao, Christina Frymire
| Nature Verified
Abstract Immune imprinting, in which prior antigenic exposures biases recall toward dominant epitopes, constrains the breadth and durability of influenza vaccine protection. Here we show that targeted variation across multiple hemagglutinin (HA) head sites (A, B, and D) between sequential A(H3N2) vaccines reprograms epitope hierarchy—redirecting recall toward conserved, subdominant head and stem epitopes.
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