John Manzi on Muck Rack

John Manzi

As seen in: Harnesslink, Nature, Science Magazine, Post and Courier, Dove Medical Press, The Times Herald-Record, The Journal of Biological Chemistry, Standardbred Canada
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Articles

Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion

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By John Manzi, Christophe Le Clainche, Gwendal Guerin, Julien Heuvingh
| biorxiv.org
Abstract Phosphatidylinositol phosphate (PIP) lipids, located on the inner leaflet of the membrane facing the cytoplasm, are key regulators of a wide range of cellular events at the plasma membrane, in some cases by interacting with partner proteins that regulate actin assembly. Supported lipid bilayers (SLBs) have been recognized as a powerful model membrane to dissect the mechanisms underlying the clustering and interactions of PIP lipids with their partner proteins.
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Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction - Nature Communications Original

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By Oleg Mikhajlov, Ram M. Adar, John Manzi, Jean-François Joanny
| Nature Verified
Abstract Integrin clusters facilitate mechanical force transmission (mechanotransduction) and regulate biochemical signaling during cell adhesion. However, most studies have focused on rigid substrates. On fluid substrates like supported lipid bilayers (SLBs), integrin ligands are mobile, and adhesive complexes are traditionally thought unable to anchor for cell spreading. Here, we demonstrate that cells spread on SLBs coated with Invasin, a high-affinity integrin ligand.
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Type 1 Gaucher’s disease, concealed by recurrent malaria

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By Yekosani Mitala, John Manzi, Abraham Birungi, Branchard Mushabe
| Dove Medical Press
Introduction Gaucher disease (GD) is an autosomal recessive lysosomal storage disease (LSD), caused by over 300 mutations in the GBA1 gene located on the long arm of chromosome 1, region 2 band 1.1,2 This causes a deficiency of a key lysosomal enzyme called β-glucosidase (also known as glucocerebrosidase) in the leukocytes. This enzyme is critical in the metabolic conversion of glucosylceramides (sugar-containing fat) to glucose and ceramide.
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