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Articles by John McMurray
Baitfish that Fuel Blitzes
It was like a scene out of Hitchcock’s Birds as we rounded the corner and approached the inlet. “Hold on!” I screamed over the delightful hum of the 4-stroke outboard as I pinned the throttle and headed for the immense clouds of wheeling and diving birds. Two hats flew off and went careening into the rooster tail behind the boat, but there was no turning around to get them.
Undiagnosed Chronic Kidney Disease, Outcomes, and Finerenone in Heart Failure : The FINEARTS-HF Randomized Clinical Trial
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Undiagnosed Chronic Kidney Disease, Outcomes, and Finerenone in Heart Failure: The FINEARTS-HF Randomized Clinical Trial Supplement 1. Supplement 2. eMethods. FINEARTS-HF Participant Flow Diagram Supplement 3. Figure 1.
By John W. Ostrominski, Finnian R. Mc Causland, Brian Claggett, Akshay Desai, Pardeep S. Jhund, Alasdair Henderson, Carolyn S. P. Lam, Michele Senni, Sanjiv Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Meike Brinker, Patrick Schloemer, Katja Rohwedder, John McMurray, Scott Solomon, Muthiah Vaduganathan, Flaviana Amarante
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JAMA Cardiology
Short-term effects of combinations of heart failure therapies on blood pressure, kidney function and serum potassium
Abstract Among the most commonly cited reasons for failure to initiate comprehensive medical therapy in patients with heart failure are concerns relating to hypotension, kidney dysfunction and hyperkalemia.
Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction : The FINEARTS-HF Randomized Clinical Trial
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Finerenone and Blood Pressure in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The FINEARTS-HF Randomized Clinical Trial Hypertension is observed in approximately 90% of people with heart failure (HF) with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF),1-3 and optimal blood pressure (BP) management is a guideline-directed priority of HF management.4,5 All guideline-recommended pharmacotherapies for HFpEF treatment have been shown to lower BP, and their...
By John W. Ostrominski, Brian Claggett, Ian J. Kulac, Akshay Desai, Pardeep S. Jhund, Alasdair Henderson, Carolyn S.P. Lam, Michele Senni, Sanjiv Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Meike Brinker, Patrick Schloemer, John McMurray, Scott Solomon Verified, Muthiah Vaduganathan, Lucas Hofmeister
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JAMA Cardiology
Chasing Giant Bluefin Tuna off New York City
(Photo by Jessica Haydahl Richardson) “Are you freakin’ kidding me?!” I screamed as fish the size of Volkswagen Beetle began to blow up around the boat while dozens of menhaden sprayed around us. We were in the middle of one of the craziest feeds I’d ever seen. What made it even crazier was that we were two miles off Rockaway with an iconic New York City skyline as the backdrop. Yet, we couldn’t buy a bite … and I’m not sure we wanted one. These were 100-inch-class fish. If we managed to stick one?
The NPR1 agonist antibody XXB750 in heart failure: a phase 2 randomized trial
Abstract Therapies targeting the natriuretic peptide system have the potential to reduce death or heart failure events in heart failure with reduced ejection fraction. Here we assess XXB750, a human monoclonal antibody activating natriuretic peptide receptor 1, in patients with heart failure. Patients with heart failure and a left ventricular ejection fraction <50% were enrolled.
Finerenone, New-Onset Atrial Fibrillation, and Prognosis in HFpEF/HFmrEF—Reply
In Reply We thank Dr Shamsulddin for the insightful comments on our analysis of the FINEARTS-HF trial,1 which examined the relationship between finerenone, atrial fibrillation (AF), and outcomes in patients with mildly reduced ejection fraction or with heart failure and mildly reduced or preserved ejection fraction preserved ejection fraction.
Efficacy and Safety of Omecamtiv Mecarbil in Heart Failure With Reduced Ejection Fraction According to Age: The GALACTIC-HF Trial
JACC Journals › JACC: Heart Failure › Archives › Vol. 14 No. 2 : JACC: Heart Failure Volume 14, Number 2 Get full access to this article View all available purchase options and get full access to this article. Supplementary Material Supplementary Tables 1-9 and Supplementary Figure 1 (mmc1.docx) References 1. Regan J.A., Kitzman D.W., Leifer E.S., et al. Impact of age on comorbidities and outcomes in heart failure with reduced ejection fraction. JACC Heart Fail. 2019;7:1056-1065. 2.
Breakthrough Mineralocorticoid Receptor Agonists in Cardiovascular Care
Published: Views: 399 Likes: 0 Share: Average (ratings) Key Learning Objectives Identify clinical barriers associated with traditional aldosterone management and recognize the impact of hyperkalemia on patient outcomes and treatment adherence Evaluate the clinical evidence supporting non-steroidal MRAs, particularly finerenone, and understand their role in modern cardiovascular therapeutic strategies Apply practical strategies for implementing breakthrough MRA therapies while managing...
AHA 25: Beta-Blocker Therapy Post MI in Patients with Preserved LVEF
AHA Scientific Sessions 2025 – Dr Anna Meta Dyrvig Kristensen (Copenhagen University Hospital, Bispebjerg and Frederiksberg, DK) presents an individual patient data meta-analysis examining beta-blocker therapy after myocardial infarction in patients with preserved left ventricular ejection fraction.
AHA 25: AI-SCREEN-CA: AI-Based Software for Cardiac Amyloidosis Detection
AHA 2025 - Prof Nobuyuki Kagiyama (Juntendo University School of Medicine, Tokyo, JP) joins us to share findings from the AI-SCREEN-CA study investigating whether an artificial intelligence-based software for checking real-world echocardiography can improve the early and accurate detection of hidden cardiac amyloidosis. Findings showed that this AI software identified around 5% of the entire cohort as potentially having cardiac amyloidosis.
Reply to the letter regarding the article ‘Sacubitril/valsartan versus enalapril in chronic Chagas cardiomyopathy with heart failure: Baseline characteristics of the PARACHUTE‐HF trial’
Correspondence Reply to the letter regarding the article ‘Sacubitril/valsartan versus enalapril in chronic Chagas cardiomyopathy with heart failure: Baseline characteristics of the PARACHUTE-HF trial’ Luis Eduardo Echeverria, Luis Eduardo Echeverria Fundación Cardiovascular de Colombia, Floridablanca, Colombia Search for more papers by this authorCaroline Demacq, Caroline Demacq Novartis Pharma AG, Basel, Switzerland Search for more papers by this authorClaudio Gimpelewicz, Claudio...
Lifetime Benefits of Comprehensive Medical Therapy in Heart Failure with Mildly Reduced or Preserved Ejection Fraction - Nature Medicine
Abstract Sodium glucose co-transporter-2 inhibitors (SGLT2i) and the non-steroidal mineralocorticoid receptor antagonist (nsMRA) finerenone have each been shown to individually improve heart failure events among patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF).
Breakthrough Mineralocorticoid Receptor Agonists in Cardiovascular Care
Breakthrough Mineralocorticoid Receptor Antagonists in Cardiovascular Care brings together renowned cardiovascular experts Dr Vijay Chopra, Dr Javed Butler, Dr Dinesh Khullar, and Prof John McMurray to address critical challenges in heart failure management and hypertension treatment.
Prioritising the primary prevention of heart failure
Get full text access Log in, subscribe or purchase for full access. References 1. Martin, SS ∙ Aday, AW ∙ Allen, NB ∙ et al. Heart disease and stroke statistics: a report of US and global data from the American Heart Association Circulation. 2025; 151:41-660 2. Roth, G ∙ Dorsey, H ∙ Decleene, N ∙ et al. The global burden of heart failure: a systematic analysis for the Global Burden of Disease Study 2021 Eur Heart J. 2023; 44 ehad655.876. 3.
Reply to ‘Impact of misclassification bias on interpretation of finerenone efficacy in chronic obstructive pulmonary disease and heart failure with mildly reduced/preserved ejection fraction: A critical appraisal of the FINEARTS‐HF sub‐analysis’
Correspondence Reply to ‘Impact of misclassification bias on interpretation of finerenone efficacy in chronic obstructive pulmonary disease and heart failure with mildly reduced/preserved ejection fraction: A critical appraisal of the FINEARTS-HF sub-analysis’ Jawad H. Butt, Jawad H.
Recurrent event analyses in patients receiving maintenance dialysis and the effect of higher‐ versus lower‐dose chronic intravenous iron therapy: A report focusing on heart failure events from the PIVOTAL trial
Supporting Information Filename Description ejhf3670-sup-0001-supinfo.docxWord 2007 document , 24.6 KB Appendix S1. Supporting Information. References 1, , , , , , et al.; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Statistical methods for recurrent event analysis in cohort studies of CKD. Clin J Am Soc Nephrol 2017; 12: 2066–2073. https://doi.org/10.2215/CJN.12841216 2, . Time to move on from ‘time-to-first’: Should all events be included in the analysis of clinical trials?
Reply to ‘Further considerations on the FINEARTS‐HF trial’
We thank the authors for acknowledging our work. The diagnosis of previously unknown diabetes and pre-diabetes was based on only one measurement of glycated haemoglobin and not at least two measurements or supplementary analyses of non-fasting glucose, fasting glucose, and oral glucose tolerance, as recommended. Therefore, it is possible that some patients might have been recategorized.
Blood on My Hands
While the words “conservationist” and “preservationist” are sometimes used interchangeably, they are different. Conservationists advocate for responsible and sustainable use of natural resources, while preservationists advocate no use. I fall into the former category. I have a profound respect for the resource, as I believe most anglers do. But I kill fish. As a full-time captain, I spend the majority of my life underway, and I kill more than most. I’m not apologizing; it’s just the way it is.
No-Targeting Closures a Real Threat for Striped Bass Fishermen
Capt. McMurray is the owner of One More Cast Charters in Oceanside, NY. While there has been a lot going on with striped bass management over the last few years, I’ve only been tangentially involved. I no longer have a seat at the Atlantic States Marine Fisheries Commission (ASMFC) table, and I’m no longer associated with any fisheries advocacy group. For the most part, that’s intentional.
Finerenone in Heart Failure with Preserved Ejection Fraction | NEJM
For permission requests, please contact NEJM Reprints at reprints@nejm.org To the Editor: Solomon et al. (Oct. 24 issue)1 found that among patients with heart failure and mildly reduced or preserved ejection fraction, finerenone resulted in a lower rate of a composite of total worsening heart failure events and death from cardiovascular causes than placebo, with a rate ratio of 0.84 (95% confidence interval [CI], 0.74 to 0.95).
Coldwater Cows: Late Season Stripers on Herring
It was December 16, 2001, and after a Scotch tasting at the Angler’s Club, I had fallen asleep (read: “passed out”) on the subway back to Rockaway. It was amazing I still had my wallet, not to mention my laptop, when I awoke somewhere in Brooklyn to my phone ringing. I tried to say hello, but my voice wasn’t yet working. “Where the hell are you?” said Capt. David Azar before I could speak. We were going to make one last go of it before pulling the boat and calling it a season.
The Best Striper Topwater Lures
Topwater striper lure bites come when you least expect it. You’re fishing seemingly dead water, casting to a sod bank, or some other structure. Then out of nowhere, KABOOM! Your topwater fishing lure disappears in a ball of white water. It is violent, savage and truly magical at the same time. In my 25 plus years of guiding anglers for striped bass, I have yet to see anyone that didn’t get excited about seeing a nice striper smash a topwater lure.
HFSA 24: STEP-HFpEF: Exercise Function and Frailty Status
Video Published: Views: 44 Likes: 0 Average (ratings) HFSA 24 - We are joined virtually by Dr Mikhail Kosiborod (Saint Luke’s Mid America Heart Institute, US) to discuss findings from the STEP-HFpEF trial programme in regard to the efficacy of semaglutide according to frailty status, and exercise function at baseline. Interview Questions: 1. Could you remind us of the importance of STEP-HFpEF 2. What was the study design and patient population? 3.
HFSA 24: HU6 in Patients with Obesity and HFpEF: The HuMAIN Trial
Video Published: Views: 20 Likes: 0 Average (ratings) HFSA 2024 - We are joined by Dr Ambarish Pandey (University of Texas Southwestern Medical Center, US) to discuss the findings from HuMAIN HFpEF, a phase 2A randomized, parallel-group, placebo-controlled study of HU6 in patients with obesity and heart failure with preserved ejection fraction (HFpEF). Interview Questions: What is the reasoning behind this study? Could you tell us about the mechanism of action behind HU6?
EASD 24: Semaglutide in Pts with Impaired Kidney Function: SELECT Prespecified Analysis
EASD 24 - We are joined by Dr Helen Coulhoun (University of Edinburgh, UK) to discuss the key findings of a prespecified analysis of the SELECT trial, which investigated the effectiveness of semaglutide in reducing major cardiac events in the presence of impaired kidney function in patients with overweight and obesity.
Finerenone benefits in heart failure consistent regardless of diabetes status
You've successfully added to your alerts. You will receive an email when new content is published. Click Here to Manage Email Alerts We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com. Key takeaways: Finerenone improved outcomes in certain patients with heart failure regardless of whether they had diabetes. Finerenone was linked with reduced risk for new-onset diabetes in patients without diabetes.
EASD 24: FINEARTS-HF: Diabetes Status Analysis
EASD 24 - We are joined by Professor John McMurray (University of Glasgow, UK) to discuss the key findings from a diabetes subgroup analysis of the FINEARTS-HF study. Interview Questions: 1. What is the reasoning behind this analysis? 2. What was the study design and patient cohort? 3. What are the key findings? 4. In your opinion, what can explain this risk reduction? 5. What are the take-home messages for practice? 6. What are the next steps? Recorded remotely from Glasgow, 2024.
False Albie Addicts
False albacore (little tunny) draw raves from mid-Atlantic and Northeast anglers for their spectacular surface hits and blistering runs. Adrian E. Gray In the early 1990s I got my first look. The wind honked out of the north on the first chilly day in September. It just felt fishy. Running toward the birds, I thought at first the boils were stripers. But when the fish came up, I knew this was something different: Streamlined muscular fish with green backs slashed through baitballs at an ungodly speed.
Fly Fishing for Striped Bass
There are anglers who exclusively fly-fish for stripers. I’m not one of them. I love to fish plugs, even bait. But there’s something awesome about targeting striped bass on fly gear. Maybe it’s the challenge. Or perhaps it’s the excitement from moments like when you unfurl a perfect loop to land your fly in the path of a cruising fish and witness the striper’s predatory instincts take over, and suddenly it pounces.
Renal Denervation Takeaways From ESC Guidelines
Skip to main content Video Published: Views: 9 Likes: 0 Average (ratings) Join Prof Atul Pathak (Clinique Pasteur, FR) and Prof Sofie Brouwers (Olv Hospital Aalst, BE) in this video on 'Renal Denervation Takeaways From ESC Guidelines'. This video is supported by Related content
Catch Mid-Atlantic Tuna Near Sand Eels
Bluefin tuna migrate closer to shore in the mid-Atlantic during spring and summer, coinciding with a remarkable annual sand eel aggregation. Brian J. Skerry / National Geographic Creative It was a slow summer at Hudson Canyon off New York, but we were headed out anyway, because you can’t catch tuna when you’re dry on the dock. We weren’t halfway out when we saw life — a half-dozen whales rolling, and tails rising among what must have been 100 or more tightly packed bottlenose dolphin.
Why Baseball Legend Willie Mays, Dead at 93, Will Never Be Forgotten
The most quickly recalled memory of Willie Mays is of a catch, where the catch somehow was not the most impressive part of the play. With the score tied in Game 1 of the 1954 World Series, Mays, with his back to home plate and racing at full speed toward the center field wall at New York’s Polo Grounds, caught a prodigious drive from Cleveland’s Vic Wertz over his shoulder, more than 450 feet from home plate.
Intravenous iron and SGLT2 inhibitors in iron‐deficient patients with heart failure and reduced ejection fraction
Introduction Iron deficiency is common in patients with heart failure and is associated with anaemia and a poorer prognosis.
Left Ventricular Ejection Fraction and the Future of Heart Failure Phenotyping:
Introduction Left ventricular ejection fraction (LVEF) measurement remains a staple of heart failure (HF) research, classification, and clinical management.
Fishing with the YouTubers
Let me be clear about something before I even begin here… Mother nature hates cameras. Seriously, she does. See a whale breach 20 times? As soon as you get your phone out to record it, she’ll sound. That tuna blitz that was seemingly non-stop? Well, if you want to end it for good, stop fishing and take your camera out. Yes, of course, I’m kind of kidding. Over the years I’ve gotten some pretty cool images and a few downright epic videos (for 10 seconds or so anyway).
The Numbers Game: Is It Ever OK To Share GPS Coordinates To Offshore Bites?
“I don’t know how to put this but I’m kind of a big deal. People know me.” Maybe not in the same way they know Ron Burgundy, but yeah man, I catch a few fish. Then incessantly brag about it on social media. I know it’s lame. It’s definitely pretty irritating to those folks who want to keep the bite on the downlow, but as a guy who runs a multi-boat charter operation, I have to do this sort of thing to stay booked. So I’m sorry, but I’m not sorry. Don’t hate the player, hate the game.
With Striped Bass Conservation, How Far Are We Willing To Go?
Currently, striped bass are “overfished.” That might be hard to believe if you were one of those anglers who witnessed massive aggregations of striped bass along the coast this fall, but that doesn’t make it untrue. What overfished means in this case is that the spawning stock biomass is below a threshold used to establish whether a stock is healthy. How is that threshold determined? Well, it differs for each species.
Things To Look For in a Jig-and-Pop Boat | Sport Fishing Mag Original
There are a few features need to run-and-gun some of the fastest fish in the ocean. Courtesy Contender After a stint in the U.S. Coast Guard as a small-boat coxswain and marine-fisheries law enforcement officer, Capt. McMurray founded One More Cast Charters. For the better part of the past two decades, he has been chasing tuna off Long Island’s South Shore, priding himself on his ability to catch tuna using spinning gear—there’s no trolling on his boat.
Effect of Dapagliflozin Versus Placebo on Symptoms and 6-Minute Walk Distance in Patients With Heart Failure: The DETERMINE Randomized Clinical Trials
BACKGROUND: Sodium-glucose cotransporter 2 inhibitors reduce the risk of worsening heart failure (HF) and cardiovascular death in patients with HF irrespective of left ventricular ejection fraction. It is important to determine whether therapies for HF improve symptoms and functional capacity.
HFA 23: The DELIVER Phase III Trial
"Hello, my name is Martin Cowie, I’m a professor of cardiology. I’m clinical vice president of late stage CVRM, R&D at AstraZeneca. What was the reasoning behind this trial? There’s a huge unmet need in terms of patient symptoms and mortality for those that have a particular form of heart failure called HFpEF with ejection fractions above 40%.And until we had the evidence from SGLT2inhibitors, there was no therapy that had been shown to improve the outcome for those patients. So, a huge unmet need.
How to Manage Heart Failure With Preserved Ejection Fraction: Practical Guidance for Clinicians
JACC Journals › JACC: Heart Failure › Archives › Vol. 11 No. 6 Abstract Although patients with heart failure with preserved ejection fraction (HFpEF) (left ventricular ejection fraction ≥50%) comprise nearly half of those with chronic heart failure, evidence-based treatment options for this population have historically been limited.
Efficacy of implantable haemodynamic monitoring in heart failure across ranges of ejection fraction: a systematic review and meta-analysis
Discussion The main results of this meta-analysis support the use of IHM in patients with symptomatic HF (irrespective of EF), demonstrating a 26% reduction in the risk of total worsening HF events, including hospital admission. This is the first meta-analysis to include total HF events from all IHM randomised trials, including LAPTOP-HF and the recently reported GUIDE-HF. We also report for the first time meta-analyses of the effectiveness of IHM-guided care in patients with HFrEF and HFpEF.
Five Things You Just Don’t Say Over the VHF
Captains have the responsibility to be respectful and professional over the VHF radio. Act like you’ve been there before. Jim Hendricks / Sport Fishing VHF radios are useful tools, and not just for safety reasons. They’re also good to quickly and efficiently communicate with other folks on the water. Monitoring radio traffic can help anglers get a general idea of what’s going on with the fleet, who is catching and who isn’t, and which anglers are having success.
Discontinuation and reinitiation of SGLT-2 inhibitors and GLP-1R agonists in patients with type 2 diabetes: a nationwide study from 2013 to 2021
Summary Background Small observational studies have observed poor persistency to sodium-glucose cotransporter-2 inhibitors (SGLT2-i) and glucacon-like-peptide-1-receptor agonists (GLP1-RA), contrary to what has been reported in clinical trials. Therefore, we investigated the risk of discontinuing SGLT2-is and GLP1-RAs in patients with type 2 diabetes (T2D) in a nationwide population.
Dapagliflozin benefits consistent in HF for patients with, without gout
Source/Disclosures Disclosures: The DAPA-HF and DELIVER trials were funded by AstraZeneca.
How to Know When the Fat Lady Has Sung on Your Fishing Season
When the weather gets really cold, big striped bass like this one will be south of New York. Capt. John McMurray Certainly, in most of the world anyway, every fishing season ends at some point. But wherever you fish, sometimes it’s hard to know when the show is over. Plus, there’s likely a bit of variance each year. In my neck of the woods of the New York Bight, the season generally runs from April through November. And after that?
Efficacy of omecamtiv mecarbil in heart failure with reduced ejection fraction according to N‐terminal pro‐B‐type natriuretic peptide level: Insights from the GALACTIC‐HF trial
Research Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ejhf.2763.
Efficacy of implantable haemodynamic monitoring in heart failure across ranges of ejection fraction: a systematic review and meta-analysis
http://orcid.org/0000-0002-1795-7445James P Curtain, Matthew M Y Lee, John JV McMurray, Roy S Gardner, Mark C Petrie, Pardeep S Jhund BHF Cardiovascular Research Centre, University of Glasgow, Institute of Cardiovascular and Medical Sciences, Glasgow, UK Correspondence to Professor Pardeep S Jhund, BHF Cardiovascular Research Centre, University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow G12 8TA, UK; Pardeep.Jhund{at}glasgow.ac.uk Abstract Aims We conducted a...
Cost-Effectiveness of Dapagliflozin as a Treatment for Chronic Kidney Disease
Discussion In this study, we developed a model driven by patient-level data from the pivotal DAPA-CKD trial to evaluate the potential long-term clinical and economic effects of dapagliflozin in the treatment of CKD. Our analysis indicates that dapagliflozin is expected to be a cost-effective treatment versus placebo when used in addition to standard therapy for a population reflective of the DAPA-CKD trial.
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