Abbreviations AE (adverse event) DLBCL (diffuse large B-cell lymphoma) EUS-TA (EUS-guided tissue acquisition) FNB (fine-needle biopsy) IHC (immunohistochemistry) IRB (Institutional Review Board) NPV (negative predictive value) OR (odds ratio) TA (tissue acquisition) Introduction Lymphadenopathy has diverse causes, including reactive changes, infections, and malignancies.1 Among these, lymphomas are a major concern.