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Joia K. Capocchi on Muck Rack

Joia K. Capocchi

As seen in: Nature, Cell Press
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Articles

Functional chimeric mRNAs encode proteins in mammalian immunity

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By Harry Kane, Gang Du, Hannah D. Coughlan, Timothy Johanson, Hongshen Wang, Pathricia Veronica Tilstam, Samuel W. Kazer, Georgia Gunner, Daisy Hoagland, Megha G. Basavappa, Kanchana R. Ravichandran, Ademi Zhakyp, Sandhya Kumar, Coco Duizer, Leonel Joannas, Shilong Yang, Liam Healy, Qiankun Wang, Joia K. Capocchi, Sarah A. Slavoff, Liang Shan, Jorge Henao-Mejia, Ruth Franklin, Isaac M. Chiu, Jose Ordovas-Montanes, Kate Jeffrey, Judy Lieberman, Rhys S. Allan, Jonathan Kagan, Hao Wu, Ruaidhri Jackson, Olivia Venezia, Eren Ada, Owen Searle, Chris Geo Provido, Bahawar Sharif Dhillon
| Nature Verified
Abstract Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci, with isoform diversity arising through cis-splicing of pre-mRNA. Whether mRNA from distant genes can undergo trans-splicing to generate functionally relevant chimeric transcripts has remained unclear. Here we develop a pipeline combining long-read direct RNA sequencing with non-targeted and targeted validation to identify chimeric transcripts in macrophages.
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