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Pathricia Veronica Tilstam on Muck Rack

Pathricia Veronica Tilstam

As seen in: Nature, The Journal of Biological Chemistry
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Articles

Functional chimeric mRNAs encode proteins in mammalian immunity

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By Harry Kane, Gang Du, Hannah D. Coughlan, Timothy Johanson, Hongshen Wang, Pathricia Veronica Tilstam, Samuel W. Kazer, Georgia Gunner, Daisy Hoagland, Megha G. Basavappa, Kanchana R. Ravichandran, Ademi Zhakyp, Sandhya Kumar, Coco Duizer, Leonel Joannas, Shilong Yang, Liam Healy, Qiankun Wang, Joia K. Capocchi, Sarah A. Slavoff, Liang Shan, Jorge Henao-Mejia, Ruth Franklin, Isaac M. Chiu, Jose Ordovas-Montanes, Kate Jeffrey, Judy Lieberman, Rhys S. Allan, Jonathan Kagan, Hao Wu, Ruaidhri Jackson, Olivia Venezia, Eren Ada, Owen Searle, Chris Geo Provido, Bahawar Sharif Dhillon
| Nature Verified
Abstract Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci, with isoform diversity arising through cis-splicing of pre-mRNA. Whether mRNA from distant genes can undergo trans-splicing to generate functionally relevant chimeric transcripts has remained unclear. Here we develop a pipeline combining long-read direct RNA sequencing with non-targeted and targeted validation to identify chimeric transcripts in macrophages.
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A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity

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By Pathricia Veronica Tilstam, Georgios Pantouris, Michael Corman, Monica Andreoli
| The Journal of Biological Chemistry Verified
Pathricia Veronica Tilstam‡, Georgios Pantouris§, Michael Corman¶, Monica Andreoli¶, Keyvan Mahboubi¶, Gary Davis¶, Xin Du‡, Lin Leng‡, Elias Lolis§,‖ and Richard Bucala‡,‖1 ‡Department of Medicine, Yale School of Medicine, New Haven, Connecticut 06510 §Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06510 ¶The Institutes for Pharmaceutical Discovery, LLC, Branford, Connecticut 06405 ‖Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut 06510 ↵1 To...
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A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity

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By Georgios Pantouris, Pathricia Veronica Tilstam, Michael Corman, Monica Andreoli
| The Journal of Biological Chemistry Verified
Pathricia Veronica Tilstam1, Georgios Pantouris2, Michael Corman3, Monica Andreoli3, Keyvan Mahboubi3, Gary Davis3, Xin Du1, Lin Leng1, Elias Lolis2 and Richard Bucala4* 1Department of Medicine, Yale University School of Medicine, New Haven, CT, United States 2Department of Pharmacology, Yale University School of Medicine, New Haven, CT, United States 3The Institutes for Pharmaceutical Discovery, LLC, Branford, CT, United States 4Medicine, Department of Medicine, Yale University School of...
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