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Jonathan Barra on Muck Rack

Jonathan Barra

As seen in: Nature, Cell Stem Cell
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Articles

Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains

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By Louise A. Mesentier-Louro, Camille Goldman, Alice Buonfiglioli, Dimitrios Kyriakis, Alain Ndayisaba, John F. Fullard, Evelyn Hennigan, Donghoon Lee, Braxton R. Schuldt, Jonathan Barra, Jose Javier Bravo-Cordero, Panos Roussos, Vikram Khurana, Joel Blanchard, Sebastian Gaese, Ashley Harlock, Emily R. Sartori, Abigail Uchitelev, Rikki B. Rooklin
| Cell Stem Cell Verified
Differentiation of human iPSCs into neurons Neuron differentiation was adapted from Zhang et al.28 and Lam et al.29 Briefly, iPSCs were transfected with PiggyBac plasmids to confer doxycycline-inducible expression of the Neurogenin- 2 gene (NGN2, Addgene Plasmid #209077) alone or in combination with SNCA-A53T-sfGFP (Addgene Plasmid: 209080) or A53T-ΔNAC-SNCA-sfGFP (Addgene Plasmid: 209081), using LipofectamineTM Stem Transfection Reagent.
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DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth - Oncogene

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By Jose Javier Bravo-Cordero, Ruslan I. Dmitriev, John LaMar, Jonathan Barra
| Nature Verified
Abstract Transient early endosome (EE)-mitochondria interactions can mediate mitochondrial iron translocation, but the associated mechanisms are still elusive. We showed that Divalent Metal Transporter 1 (DMT1) sustains mitochondrial iron translocation via EE-mitochondria interactions in triple-negative MDA-MB-231, but not in luminal A T47D breast cancer cells. DMT1 silencing increases labile iron pool (LIP) levels and activates PINK1/Parkin-dependent mitophagy in MDA-MB-231 cells.
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