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ORIGIN 3 Plenary Highlights: Atacicept Shows Remarkable IgAN Results
At the 2026 American Society of Nephrology (ASN) Kidney Week, Joel Topf, MD, Henry Ford Health, speaks with Jonathan Barratt, MD, University of Leicester, after his plenary session presentation on the ORIGIN 3 trial, discussing final data showing that atacicept significantly slowed kidney function decline in high-risk IgA nephropathy and restored rates of kidney function loss to levels comparable with those seen in healthy individuals.
Jonathan Barratt, MBChB, PhD
Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of Formedics, its employees, and affiliates.
Atacicept-vymj meets all 2-year prespecified endpoints for adults with IgA nephropathy
Key takeaways: No patients in the atacicept-vymj group required dialysis or transplantation or died. The data will be submitted for full FDA approval. DENVER — Atacicept-vymj stabilized eGFR, reduced risks for a composite kidney disease progression outcome and was well tolerated vs. placebo for adults with immunoglobulin A nephropathy, according to findings presented at ASN Kidney Week.
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