Articles by Jonathan M
Genomic profiling and drug resistance patterns of Mycobacterium tuberculosis in Indonesia: whole-genome sequencing of isolates from the 2017–2018 national Tuberculosis Drug Resistance Survey
Abstract Objective: Drug-resistant tuberculosis remains a major public health challenge in Indonesia. This study aimed to characterize the genetic diversity, lineage distribution, and genotypic resistance profiles of Mycobacterium tuberculosis isolates across the Indonesian archipelago using whole-genome sequencing. Methods: A cross-sectional study was conducted using 1,281 analyzed MTB isolates derived from the 2017–2018 National Tuberculosis Drug Resistance Survey (DRS TB).
Supercharged penguins—supplementary feeding reshapes tawaki/Fiordland penguin winter migration
Supercharged penguins—supplementary feeding reshapes tawaki/Fiordland penguin winter migration 1Department of Marine Science, University of Otago, Dunedin, New Zealand 2The Tawaki Trust, Dunedin, New Zealand 3Global Penguin Society, Marcos Zar, Puerto Madryn, Chubut, Argentina 4Department of Zoology, University of Otago, Dunedin, New Zealand 5Antarctic Reseach Trust, Am Oste-Hamme-Kanal, Bremervörde, Germany 6Antarctic Research Trust, c/o Zoo Zürich, Zürichbergstr, Zürich, Switzerland DOI...
From promise to proof: reference sets for validation of multicancer early detection
The Alliance Reference Set Study is the first to compare different commercial multicancer detection (MCD) tests on a single set of clinical samples from patients with cancer and volunteers without cancer.1 Previously, the only similar study compared several prototype approaches for analyzing cell-free DNA, to determine the most promising analytes for further test development.2 They show that MCD tests have clinical validity but that none of those studied are outstanding, and the heterogeneity...
A Machine Learning Free Energy Functional for the 1D Reference Interaction Site Model: Towards Prediction of Solvation Free Energy for All Solvent Systems
1. Introduction Solvation Free Energy The process of solvation, as defined by Ben-Naim, is the transfer of one solute molecule from a fixed position in the ideal gas phase to a fixed position in the liquid phase at a given temperature and pressure [1]. The solvation free energy (SFE) is the reversible work associated with the transfer of the solute molecule from the gas phase to the liquid phase.
Risk of type 2 diabetes, MASLD and cardiovascular disease in people living with polycystic ovary syndrome
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The use of technology in type 2 diabetes and prediabetes: a narrative review - Diabetologia
Abstract The increasing incidence of type 2 diabetes, which represents 90% of diabetes cases globally, is a major public health concern. Improved glucose management reduces the risk of vascular complications and mortality; however, only a small proportion of the type 2 diabetes population have blood glucose levels within the recommended treatment targets.
Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development - Cell Death & Disease
Abstract Within the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T cell development and selection. Considering that TECs are sensitive to distinct pathophysiological conditions, uncovering the molecular elements that coordinate their thymopoietic role has important fundamental and clinical implications. Particularly, medullary thymic epithelial cells (mTECs) play a crucial role in central tolerance.
Practical Comparison of Two- and Three-Phase Bearingless Permanent Magnet Slice Motors for Blood Pumps
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Co-translational assembly orchestrates competing biogenesis pathways - Nature Communications
Abstract During the co-translational assembly of protein complexes, a fully synthesized subunit engages with the nascent chain of a newly synthesized interaction partner. Such events are thought to contribute to productive assembly, but their exact physiological relevance remains underexplored. Here, we examine structural motifs contained in nucleoporins for their potential to facilitate co-translational assembly.
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