Jonathan Steinman
San Francisco Bay
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Articles by Jonathan Steinman
Targeting allostery in the Dynein motor domain with small molecule inhibitors
Highlights • A chemical inhibitor of Saccharomyces cerevisiae dynein enables structural studies • Structural data indicate that the inhibitor binds dynein's regulatory ATPase sites • Blocking AAA3 and AAA4 sites in the motor protein can inhibit its activity • Data provide a structural framework that can aid in inhibitor optimization Summary Cytoplasmic dyneins are AAA (ATPase associated with diverse cellular activities) motor proteins responsible for microtubule minus-end-directed...
Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics
Reduced development of COVID-19 in children reveals molecular checkpoints gating pathogenesis illuminating potential therapeutics Jonathan Baruch Steinman, Fok Moon Lum, Peggy Pui-Kay Ho, Naftali Kaminski, Lawrence Steinman Proceedings of the National Academy of Sciences Sep 2020, 202012358; DOI: 10.1073/pnas.2012358117
Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins
Highlights • Testing compounds against engineered mutant alleles of target leads to binding model • High-resolution X-ray structures confirm predicted models • Cognate inhibitor resistance-conferring mutations are identified • This approach can be applied to multiple chemical scaffolds Summary Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes.
Flu Season Is Here: What You Need To Know
(NEW YORK) — It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
Flu season is here: What you need to know
Flu season is here: What you need to know iStock/Thinkstock(NEW YORK) — It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
KTBB.com - News Weather Talk
iStock/Thinkstock(NEW YORK) -- It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
Flu season is here: What you need to know - Health News - ABC News Radio
iStock/Thinkstock(NEW YORK) -- It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
KTBB.com - News Weather Talk
iStock/Thinkstock(NEW YORK) — It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
Flu season is here: What you need to know
By Dr. Jonathan Steinman(NEW YORK) -- It’s the start of fall, which means flu season is here.Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths.Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
Flu season is here: What you need to know about the flu vaccine
(ABC NEWS) -- It’s the start of fall, which means flu season is here. Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths. Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
October is Breast Cancer Awareness Month: What to know about the latest developments in breast cancer research, treatment and prevention
Breast Cancer Awareness Month kicks off on Tuesday. Often associated with pink ribbons and 5K walks, the movement has been wildly popular; National Cancer Institute (NCI) funding for breast cancer totaled $520 million in 2016. The increasing breast cancer awareness comes at a time when women can find substantial improvements in breast cancer treatment. Here’s what you need to know about the latest developments. How common is breast cancer?
Flu season is here
By Dr. Jonathan Steinman(NEW YORK) -- It’s the start of fall, which means flu season is here.Last year, flu hospitalizations were the highest they’ve ever been; 106 out of every 100,000 people were hospitalized for the flu in the 2017-18 season, with people over age 65 accounting for 58 percent of those hospitalizations and 180 pediatric deaths.Flu and the common cold can both make you feel crummy, but they are caused by different viruses.
Kavanaugh accuser Christine Blasey Ford describes memory science, hippocampus in emotional Senate testimony
During her testimony to the Senate Judiciary Committee Thursday regarding her allegation that Supreme Court nominee Brett Kavanaugh sexually assaulted her 36 years ago, senators asked Christine Blasey Ford directly about the judge’s claim that it may be a case of mistaken identity.
Newer hormonal birth control linked to lower ovarian cancer risk: Study
Hormonal contraception methods like a pill, patch, ring or injectable are very effective and popular as birth control, but they can have other health benefits, too. Most of the over 100 million women who use hormonal contraceptives daily are prescribed them for birth control, but a new study says estrogen-containing contraceptives may also lower the risk of ovarian cancer, even years after discontinuing use.
Mediterranean diet could lower stroke risk, especially for women: Study
Can following a Mediterranean diet lower the risk of stroke? A new study says possibly -- and especially for women. Mediterranean diets, which encourage eating fruits, vegetables, nuts, fish, and unsaturated fats, have been associated with lower rates of heart disease and strokes. Research on the subject has been of variable quality, failing to account for people's cardiovascular risks or how strictly they followed their diets.
Long-term effects of ADHD? Study links disorder to Parkinson's, but don't be alarmed
Attention-deficit/hyperactivity disorder (ADHD) is a common condition in kids, affecting their behavior and ability to learn in the classroom. The neurodevelopmental disorder affects an estimated 11 percent of children and teens between the ages of 4 and 17, according to the Centers for Disease Control and Prevention. However, with medication and other treatments, it’s quite manageable. That said, a new study finds a link between ADHD, its meds, and Parkinson’s disease.
Scientists say they've developed blood test that can detect internal body clock
(NEW YORK) — Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field. Scientists believe someone’s internal clock is a key to figuring out how their body works.
KTBB.com - News Weather Talk
(NEW YORK) — Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field. Scientists believe someone’s internal clock is a key to figuring out how their body works.
Scientists say they’ve developed blood test that can detect internal body clock
(NEW YORK) — Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field. Scientists believe someone’s internal clock is a key to figuring out how their body works.
Scientists say they've developed blood test that can detect internal body clock - Health News - ABC News Radio
iStock/ThinkstockBY: DR. JONATHAN STEINMAN (NEW YORK) -- Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field.
KTBB.com - News Weather Talk
iStock/ThinkstockBY: DR. JONATHAN STEINMAN (NEW YORK) -- Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field.
Scientists say they've developed blood test that can detect internal body clock
Can a blood test tell what time it is in your body? Scientists at Northwestern University think so. In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm. Circadian rhythms are a major area of research in the medical field. Scientists believe someone’s internal clock is a key to figuring out how their body works.
Scientists say they've developed blood test that can detect internal body clock
BY: DR. JONATHAN STEINMAN(NEW YORK) -- Can a blood test tell what time it is in your body? Scientists at Northwestern University think so.In a study published Monday in the medical journal PNAS, researchers reveal that they have invented a new computer algorithm called “TimeSignature” that uses blood sample data to predict someone’s circadian rhythm.Circadian rhythms are a major area of research in the medical field.
KTBB.com - News Weather Talk
(NEW YORK) — Tuberculosis (TB), a lung disease most often transmitted by breathing infected particles in the air, is the ninth leading cause of death worldwide. An estimated 10.4 million people fell ill with TB in 2016, and about 1.7 million died. The most dangerous type — multidrug-resistant tuberculosis, or MDR-TB — can’t be cured by the usual rounds of antibiotics. But a new study finds significant success in new treatment options.
The dangers of drug-resistant tuberculosis: What you need to know
Tuberculosis, a lung disease most often transmitted by breathing infected particles in the air, is the ninth leading cause of death worldwide. An estimated 10.4 million people fell ill with TB in 2016, and about 1.7 million died. The most dangerous type -- multidrug-resistant tuberculosis or MDR-TB -- can't be cured by the usual rounds of antibiotics. But a new study finds significant success in new treatment options.
Doctors single out antibiotics with better cure rates for tuberculosis
By DR. JONATHAN STEINMAN(NEW YORK) -- Tuberculosis (TB), a lung disease most often transmitted by breathing infected particles in the air, is the ninth leading cause of death worldwide. An estimated 10.4 million people fell ill with TB in 2016, and about 1.7 million died. The most dangerous type -- multidrug-resistant tuberculosis, or MDR-TB -- can't be cured by the usual rounds of antibiotics. But a new study finds significant success in new treatment options.
Expert panel recommends against routine blood screening for prostate cancer: Report
(NEW YORK) — An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer. Using this screening test led to no significant decrease in overall patient death, according to the study.
KTBB.com - News Weather Talk
(NEW YORK) — An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer. Using this screening test led to no significant decrease in overall patient death, according to the study.
Expert panel recommends against routine blood screening for prostate cancer: Report
(NEW YORK) — An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer. Using this screening test led to no significant decrease in overall patient death, according to the study.
KTBB.com - News Weather Talk
iStock/ThinkstockBY: DR. JONATHAN STEINMAN (NEW YORK) -- An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer.
Expert panel recommends against routine blood screening for prostate cancer: Report - Health News - ABC News Radio
iStock/ThinkstockBY: DR. JONATHAN STEINMAN (NEW YORK) -- An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer.
Expert panel recommends against routine blood screening for prostate cancer: Report
An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ. The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer. Using this screening test led to no significant decrease in overall patient death, according to the study.
Expert panel recommends against routine blood screening for prostate cancer: Report
BY: DR. JONATHAN STEINMAN(NEW YORK) -- An expert panel has recommended against routine blood screening for prostate cancer, in a report published Wednesday in The BMJ.The panel, composed of general practitioners, urologists, methodologists and patients, cited five clinical trials which evaluated the use of a blood test for prostate-specific antigen (PSA) in screening for prostate cancer.
Impact of a Structured Reporting Template on Adherence to Prostate Imaging Reporting and Data System Version 2 and on the Diagnostic Performance of Prostate MRI for Clinically Significant Prostate Cancer - Journal of the American College of Radiology
Improved Quality of Thyroid Ultrasound Reports After Implementation of the ACR Thyroid Imaging Reporting and Data System Nodule Lexicon and Risk Stratification System
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