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José Luiz Proenca-Modena on Muck Rack

José Luiz Proenca-Modena

As seen in: Nature, Cell Reports Medicine, The Lancet
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Articles

Transmission dynamics of Oropouche virus in Latin America and the Caribbean

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By Erika R. Manuli, Xinyi Hua, Gabriel C Scachetti, Julia Forato, Ingra M Claro, Geovana M. Pereira, Lívia Sacchetto, Oscar Cortes-Azuero, Ligia Capuani, Ronaldo de Jesus, Barbara Salgado, Renato Reis, Sergio Albuquerque, Richard Stanton, Vanderson S Sampaio, Ana I. Bento, Oliver Ratmann, Nuno R Faria, Scott Weaver, Pritesh Lalwani, Henrik Salje, Allyson G. Costa, José Luiz Proenca-Modena, William de Souza, Ana Carolina Bernardo, Cláudia F. Resende, Natália B. S. Bacarov, Shirlene T. S. de Lima, Rodrigo B. Kato, Carolina M. L. Singh, Nadielle C. Pereira, Marielton P. Cunha
| Nature Verified
Abstract Oropouche virus (OROV) is an arbovirus endemic to the Amazon region since the 1950s that re-emerged in late 2023, causing a major epidemic across Central and South America. Here we investigated the transmission dynamics of the 2023–2024 epidemic in Manaus City (Amazonas state, Brazil), a major metropolitan hub in the Amazon, and estimated OROV infections across Latin America and the Caribbean.
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Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery

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By Jiajing Li, Xin Wang, Yibo Ding, Fang Qin, Lito Papamichail, Rick Schraauwen, Julia Forato, Ingra M Claro, Xinyi Hua, Monique M.A. Verstegen, Marjan Boter, Maikel P. Peppelenbosch, Anna Barbiero, Elisabetta Pagani Verified, Harry Janssen, Jose Silva, José Silva, Eder C. Pincinato, José Luiz Proenca-Modena, Pengfei Li, Adam A. Anas, Concetta Castilletti, William de Souza, Wenshi Wang, Qiuwei Pan, Shirlene T.S. de Lima, Leda M. Simões Mello, Luc J.W. van der Laan, Bas B. Oude Munnink
| Cell Reports Medicine Verified
Keywords Oropouche emergence liver organoids therapeutic discovery Introduction Oropouche virus (OROV) is a neglected vector-borne pathogen that causes Oropouche fever, first identified in Latin America and the Caribbean in 1955.1 In late 2023, it re-emerged in the Brazilian Amazon and quickly spread eastward, establishing transmission across all regions of Brazil by 2024.2,3,4 Endemic circulation has also been reported in Barbados, Bolivia, Colombia, Cuba, the Dominican Republic, Ecuador,...
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Re-emergence of Oropouche virus between 2023 and 2024 in Brazil: an observational epidemiological study

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By Ministério da Sáude, Departamento de Patologia, José Luiz Proenca-Modena
| The Lancet Verified
Introduction Oropouche virus is an endemic and neglected arbovirus that causes Oropouche fever in central and South America.1 Oropouche fever is usually characterised by mild and self-limited, non-specific disease with headache, arthralgia, myalgia, nausea, vomiting, chills, and photophobia.1 However, some people can have more severe complications, such as haemorrhagic manifestations, meningitis, meningoencephalitis, pregnancy complications (eg, stillbirths and congenital disabilities,...
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