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Shirlene T.S. de Lima

As seen in: Cell Reports Medicine
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Articles

Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery

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By Jiajing Li, Xin Wang, Yibo Ding, Fang Qin, Lito Papamichail, Rick Schraauwen, Julia Forato, Ingra M Claro, Xinyi Hua, Monique M.A. Verstegen, Marjan Boter, Maikel P. Peppelenbosch, Anna Barbiero, Elisabetta Pagani Verified, Harry Janssen, Jose Silva, José Silva, Eder C. Pincinato, José Luiz Proenca-Modena, Pengfei Li, Adam A. Anas, Concetta Castilletti, William de Souza, Wenshi Wang, Qiuwei Pan, Shirlene T.S. de Lima, Leda M. Simões Mello, Luc J.W. van der Laan, Bas B. Oude Munnink
| Cell Reports Medicine Verified
Keywords Oropouche emergence liver organoids therapeutic discovery Introduction Oropouche virus (OROV) is a neglected vector-borne pathogen that causes Oropouche fever, first identified in Latin America and the Caribbean in 1955.1 In late 2023, it re-emerged in the Brazilian Amazon and quickly spread eastward, establishing transmission across all regions of Brazil by 2024.2,3,4 Endemic circulation has also been reported in Barbados, Bolivia, Colombia, Cuba, the Dominican Republic, Ecuador,...
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