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ArticleOnline now102651Open access Affiliations & Notes 1Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain 2Universitat Pompeu Fabra (UPF), Barcelona, Spain 3Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Frankfurt, Germany 4Goethe University Frankfurt, University Hospital, Department of Neurology, Frankfurt, Germany 5Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Frankfurt, Germany 6Goethe...
Abstract Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. We characterized the whole genome, epigenome and transcriptome, combined with single-cell DNA/RNA-sequencing analyses and functional experiments, of 19 cases of CLL developing RT.
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