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Juejia Shao on Muck Rack

Juejia Shao

As seen in: Nature
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Articles

Spatial partitioning of NSD2 defines H3K36me2 as an active mark for repetitive sequence activation

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By Junqi Jia, Yu Chi Liu, Jiamin Yu, Jingwei Wang, Yiting Zhang, Yuan Fang, Ying Yu, Zhongxing Sun, Zhuoning Li, Yin Tang, Yanjun Zhang, Hai Song, Sergey V. Ulianov, Jing Huang, Dong Fang, Juejia Shao
| Nature Verified
Abstract Histone H3 lysine 36 dimethylation (H3K36me2) plays a key role in transcriptional elongation and chromatin organization, yet how its deposition is spatially controlled across the genome remains unclear. Here, we identify TOP1 as a critical recruiter of the H3K36me2 methyltransferase NSD2 to gene bodies. Disruption of the TOP1–NSD2 interaction reduces H3K36me2 at gene bodies, impairs RNA polymerase II release, and represses transcription.
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