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Juliet M. Bartleson on Muck Rack

Juliet M. Bartleson

As seen in: Nature, The Journal of Clinical Investigation, The Journal of Immunology
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Articles

Cell-type-specific surfaceome profiling of 100-500 isolated cells using a droplet-based Magnetic Affinity Purification System

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By Amanda Lorentzian, Juliet M. Bartleson, Terence Ho, Hao Xu, Christopher Bullock, Zhichang Yang, Alan Gutierrez, Alan Gutiérrez, Meena Choi, Tommy K Cheung, Christopher Rose, Hua Zhang, William T. Yewdell, Ying Zhu
| Nature Verified
Abstract Cell surface proteins represent an important source of biomarkers and therapeutic targets. However, due to the inherent sensitivity limitations of existing technologies, tissue and cell-type-specific surfaceomes remain poorly characterized, especially in the context of human diseases.
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Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

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By Charlotte Domblides, Steven Crampton, Hong liu, Juliet M. Bartleson
| The Journal of Clinical Investigation
Abstract The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown.
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Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions

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By Paul Allen, Juliet M. Bartleson, David L. Donermeyer, Stephen Horvath
| Nature Verified
Abstract T follicular helper (TFH) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives the initiation of their developmental program remains unclear. Studies suggest that a T cell antigen receptor (TCR)-dependent mechanism may be responsible for the earliest TFH cell–fate decision, but a critical aspect of the TCR has been overlooked: tonic TCR signaling. We hypothesized that tonic signaling influences early TFH cell development.
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