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Juliet M. Bartleson on Muck Rack

Juliet M. Bartleson

As seen in: Nature, The Journal of Clinical Investigation, The Journal of Immunology
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Articles

Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

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By Charlotte Domblides, Steven Crampton, Hong liu, Juliet M. Bartleson
| The Journal of Clinical Investigation
Abstract The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown.
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Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions

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By Paul Allen, Juliet M. Bartleson, David L. Donermeyer, Stephen Horvath
| Nature Verified
Abstract T follicular helper (TFH) cells are critical in adaptive immune responses to pathogens and vaccines; however, what drives the initiation of their developmental program remains unclear. Studies suggest that a T cell antigen receptor (TCR)-dependent mechanism may be responsible for the earliest TFH cell–fate decision, but a critical aspect of the TCR has been overlooked: tonic TCR signaling. We hypothesized that tonic signaling influences early TFH cell development.
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Tonic TCR Signaling Inversely Regulates the Basal Metabolism of CD4+ T Cells

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By Juliet M. Bartleson, Michael D. Buck, Chih-Hao Chang, Alexey Sergushichev
| immunohorizons.org
Open Access Ashley A. Viehmann Milam, Juliet M. Bartleson, Michael D. Buck, Chih-Hao Chang, Alexey Sergushichev, David L. Donermeyer, Wing Y. Lam, Erika L. Pearce, Maxim N. Artyomov and Paul M. Allen ImmunoHorizons August 1, 2020, 4 (8) 485-497; DOI: https://doi.org/10.4049/immunohorizons.2000055 Abstract The contribution of self-peptide–MHC signaling in CD4+ T cells to metabolic programming has not been definitively established.
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