Articles by Jun Chen
Clinical Value of Four Cytokines-Based Laboratory Parameters in Assessing Disease Severity in Patients with Severe Fever With Thrombocytopenia Syndrome
1 Introduction First reported in 2009 in rural areas of central China, Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV), which has been reclassified as Dabie bandavirus [1]. Following its initial discovery, the disease has spread to more than 20 provinces across China and has also been identified in other parts of East and Southeast Asia, such as Japan, Korea, Vietnam, and Thailand [2-5].
Comments on “Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study”
Man Sun and Dan Zang contributed equally to this work. No abstract is available for this article. References 1, , , et al., “Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study,” International Journal of Cancer (2026): ijc.70486, https://doi.org/10.1002/ijc.70486.
Encapsulation of Pt Nanoparticles in ZSM-5 Zeolite for the Durable Hydrogen-Water Isotope Exchange
Conflicts of Interest The authors declared no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description cctc70983-sup-0001-SuppMat.docx915.3 KB Supporting File 1: cctc70983-sup-0001-SuppMat.docx References 1, ““Ideal” Bifunctional Catalysis Over Pt-acid Zeolites,” Catalysis Today 218 (2013): 123–134, https://doi.org/10.1016/j.cattod.2013.04.028.
Targeting peripheral 5-HT 2A R enhances antitumor immunity in colorectal cancer
Keywords 5-HT2AR agonist enteric glial cell cytotoxic CD8+ T cell colorectal cancer Get full text access Log in, subscribe or purchase for full access. References 1. Pitman, A. ∙ Suleman, S. ∙ Hyde, N. ... Depression and anxiety in patients with cancer BMJ. 2018; 361, k1415 2. Phillips, M.R. ∙ Zhang, J. ∙ Shi, Q. ... Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001–05: an epidemiological survey Lancet. 2009; 373:2041-2053 3. Cheng, V. ∙ Oveisi, N.
Structural pharmacology of TRPA1 channel
Keywords TRPA1 agonist antagonist cryo-EM binding sites drug discovery The emergence of TRPA1 as a therapeutic target The Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is the sole member of the mammalian TRPA subfamily. Predominantly expressed in nociceptive neurons (see Glossary) [1], TRPA1 functions as a polymodal receptor that integrates environmental irritants, oxidative insults, and cellular stress signals to regulate sensory signaling and neurogenic inflammation.
GLP-1 RA Therapy After Bariatric Surgery: Phenotype, Strategy and Success
To the Editor, We read with great interest the target trial emulation by Wu et al. [1], which provides timely Chinese real-world evidence that GLP-1 receptor agonist initiation may promote clinically meaningful weight loss among suboptimal responders after metabolic bariatric surgery. This work is particularly relevant as incretin-based therapies are increasingly extending beyond primary obesity management into post-bariatric rescue and maintenance care.
Mindfulness combined with cognitive motor dual task training in Parkinson’s disease with mild cognitive impairment
Subject areas Health sciences Medicine Medical specialty Internal medicine Neurology Introduction Parkinson’s disease (PD) is a common neurodegenerative disorder with a global prevalence of over 6 million.1 Motor symptoms are typical features of PD, such as tremor, rigidity, bradykinesia, and postural instability.2 However, increasing evidence indicates that health-related issues caused by non-motor symptoms are more significant.3 PD-mild cognitive impairment (PD-MCI) refers to the gradual...
Interpreting Post-Discontinuation Trajectories After Semaglutide or Tirzepatide
Man Sun and Dan Zang have contributed equally to this work. M.Sun, D.Zang, and J.Chen, “Interpreting Post-Discontinuation Trajectories After Semaglutide or Tirzepatide,” Diabetes, Obesity and Metabolism (2026): 1–2, https://doi.org/10.1111/dom.70710. No abstract is available for this article. Peer Review The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/dom.70710.
Population PK-PD Modeling of Danicopan Add‐On Therapy in Participants With Paroxysmal Nocturnal Hemoglobinuria Treated With Ravulizumab or Eculizumab
1 Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic and progressive disease of uncontrolled terminal complement activation that leads to intravascular hemolysis (IVH), thrombosis, organ damage, and increased risk of premature mortality, imposing significant burden on patients [1].
Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells
Keywords humoral immunological memory plasma cells fasting β-hydroxybutyrate long-lived plasma cells intermittent fasting vaccines ketogenic diet ketone bodies neutralizing antibody Get full text access Log in, subscribe or purchase for full access. References 1. Quast, I. ∙ Tarlinton, D. B cell memory: understanding COVID-19 Immunity. 2021; 54:205-210 2. Bhattacharya, D. Instructing durable humoral immunity for COVID-19 and other vaccinable diseases Immunity. 2022; 55:945-964 3. Akkaya, M. ∙ Kwak, K.
The Impact of Attentional Resources on Emotional Expressions Revealed by Event‐Related Potentials
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The available data and code can be found at https://osf.io/ank6u/. Supporting Information Filename Description psyp70186-sup-0001-supinfo.docxWord 2007 document , 2.7 MB Figure S1: Scalp topographies of fearful, happy, and neutral expressions from 0 to 300 ms, plotted at 30-ms intervals. The 240–280 ms maps show the face-specific activation in occipitotemporal regions.
Improve the Photoelectric Properties of Transparent Insulating Films Through Simple Mechanical Pressure Treatment
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description app56958-sup-0001-Supinfo.docxWord 2007 document , 1.7 MB Data S1. Supporting Information. References 1, , and , “Recent Advances in Mechanical Properties of Anisotropic Conductive Adhesive Film for Microelectronic Packaging,” Soldering & Surface Mount Technology 27 (2015): 164–177.
Improve the Photoelectric Properties of Transparent Insulating Films Through Simple Mechanical Pressure Treatment
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description app56958-sup-0001-Supinfo.docxWord 2007 document , 1.7 MB Data S1. Supporting Information. References 1, , and , “Recent Advances in Mechanical Properties of Anisotropic Conductive Adhesive Film for Microelectronic Packaging,” Soldering & Surface Mount Technology 27 (2015): 164–177.
Construction of Dynamic Recrystallization Critical Strain Model, Kinetic Model, and Hot Workability of Mg-8Gd-4Sm-1Zn-0.5Zr Alloy
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , , Met. Mater. Int. 2023, 29, 390. 2 , , , , , , Adv. Eng. Mater. 2023, 25, 2201046. 3 , , , , , , , , , Mater. Charact. 2018, 145, 329. 4 , , , , , , , Sci. Rep. 2021, 11, 2860. 5 , , , , , , Acta Mater. 2016, 108, 207. 6 , , , Int. J. Metalcast. 2018, 12, 897. 7 , , , , Mater. Today Commun. 2021, 28, 102627. 8 , , , , , , Philos. Mag. A 1997, 76, 1065. 9 , , , , , , , , Mater. Charact. 2014, 24, 1683. 10 , , , , , Mater. Sci.
Construction of Dynamic Recrystallization Critical Strain Model, Kinetic Model, and Hot Workability of Mg-8Gd-4Sm-1Zn-0.5Zr Alloy
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , , Met. Mater. Int. 2023, 29, 390. 2 , , , , , , Adv. Eng. Mater. 2023, 25, 2201046. 3 , , , , , , , , , Mater. Charact. 2018, 145, 329. 4 , , , , , , , Sci. Rep. 2021, 11, 2860. 5 , , , , , , Acta Mater. 2016, 108, 207. 6 , , , Int. J. Metalcast. 2018, 12, 897. 7 , , , , Mater. Today Commun. 2021, 28, 102627. 8 , , , , , , Philos. Mag. A 1997, 76, 1065. 9 , , , , , , , , Mater. Charact. 2014, 24, 1683. 10 , , , , , Mater. Sci.
Surface Molecular Engineering for Fully Textured Perovskite/Silicon Tandem Solar Cells
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Surface Molecular Engineering for Fully Textured Perovskite/Silicon Tandem Solar Cells
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Infection of Alfalfa Cotyledons by an Incompatible but Not a Compatible Species of Colletotrichum Induces Formation of Paramural Bodies and Secretion of EVs
Abstract Hemibiotrophic fungi in the genus Colletotrichum employ a biotrophic phase invading host epidermal cells followed by a necrotrophic phase spreading through neighboring mesophyll and epidermal cells. We used serial block face scanning electron microscopy (SBF-SEM) to compare subcellular changes that occur in Medicago sativa (alfalfa) cotyledons during infection by Colletotrichum destructivum (compatible on M. sativa) and C. higginsianum (incompatible on M. sativa).
Direct Photolithography Patterning of Quantum Dot‐Polymer
Conflict of Interest The authors declare no conflict of interest. References 1, , , , , , , , Adv. Mater. Technol. 2023, 8, 2200632. 2, , Opt. Express 2013, 21, A475. 3, , , , , , , , , , Appl. Sci. 2018, 8, 1557. 4, , , , , , J. Soc. Inf. Dis. 2019, 27, 387. 5, , Appl. Phys. Lett. 2020, 116, 100502. 6, , , , , Nanomaterials 2020, 10, 2482. 7, , , J. Am. Chem. Soc 1993, 115, 8706. 8, , , , , , , , , , , , Nanoscale 2016, 8, 12182. 9, , , , , , , , ACS Appl. Nano Mater. 2019, 2, 1496.
Direct Photolithography Patterning of Quantum Dot‐Polymer
Conflict of Interest The authors declare no conflict of interest. References 1, , , , , , , , Adv. Mater. Technol. 2023, 8, 2200632. 2, , Opt. Express 2013, 21, A475. 3, , , , , , , , , , Appl. Sci. 2018, 8, 1557. 4, , , , , , J. Soc. Inf. Dis. 2019, 27, 387. 5, , Appl. Phys. Lett. 2020, 116, 100502. 6, , , , , Nanomaterials 2020, 10, 2482. 7, , , J. Am. Chem. Soc 1993, 115, 8706. 8, , , , , , , , , , , , Nanoscale 2016, 8, 12182. 9, , , , , , , , ACS Appl. Nano Mater. 2019, 2, 1496.
The Dmc1 recombinase physically interacts with and promotes the meiotic crossoverfunctions of the Mlh1-Mlh3 endonuclease
Abstract The accurate segregation of homologous chromosomes during the Meiosis I reductional division in most sexually reproducing eukaryotes requires crossing over between homologs. In bakers yeast approximately 80 percent of meiotic crossovers result from Mlh1-Mlh3 and Exo1 acting to resolve double-Holliday junction (dHJ) intermediates in a biased manner.
A flexible quasi‐likelihood model for microbiome abundance count data
CONFLICT OF INTEREST STATEMENT Dr. Lei Liu is a consultant to the Adial Pharmaceuticals. Supporting Information Filename Description sim9880-sup-0001-supinfo.docxWord 2007 document , 31.3 KB Data S1. Supporting Information REFERENCES 1, . Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013; 27: 73-83. 2, , . Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care. 2010; 33(10): 2277-2284. 3, , , et al.
A flexible quasi‐likelihood model for microbiome abundance count data
CONFLICT OF INTEREST STATEMENT Dr. Lei Liu is a consultant to the Adial Pharmaceuticals. Supporting Information Filename Description sim9880-sup-0001-supinfo.docxWord 2007 document , 31.3 KB Data S1. Supporting Information REFERENCES 1, . Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013; 27: 73-83. 2, , . Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care. 2010; 33(10): 2277-2284. 3, , , et al.
White-light channeled imaging polarimeter using Savart plates and a polarization Sagnac interferometer
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Do submerged macrophyte species influence crustacean zooplankton functional group richness and their resource use efficiency in the low-light environment? - PubMed
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Benchmarking Differential Abundance Analysis Methods for Correlated Microbiome Sequencing Data
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Tunable unidirectional surface plasmon polaritons at the interface between gyrotropic and isotropic conductors
K. Shastri, M. I. Abdelrahman, and F. Monticone, “Nonreciprocal and topological plasmonics,” Photonics 8, 133 (2021). [Crossref] Y. Liang, S. Pakniyat, Y. Xiang, F. Shi, G. W. Hanson, and C. Cen, “Temperature-dependent transverse-field magneto-plasmons properties in InSb,” Opt. Mater. 112, 110831 (2021). [Crossref] S. Pakniyat, Y. Liang, Y. Xiang, C. Cen, J. Chen, and G. W. Hanson, “Indium antimonide—Constraints on practicality as a magneto-optical platform for topological surface plasmon polaritons,” J. Appl. Phys.
Learning from nature for healthcare, energy, and environment
Have you ever looked into the sky and wondered why birds could fly? Or perhaps why the leaves of cacti are needle-like? Throughout evolution, organisms have experimented with various forms and functions for over 3 billion years before the first human manipulations of stone, bone, and antler. From animal teeth to spears, fish fins to paddles, human beings have studied nature not only to satisfy curiosity but, more importantly, to learn from it for innovations and inventions.
Polarization improvement of CsPbClBr2 quantum dot film by laser direct writing technology
Abstract Inorganic halogen perovskite quantum dots not only have high fluorescence quantum efficiency, but also can emit polarized light in solution or thin film. These excellent performances make perovskite quantum dots promising to be used in next-generation displays. In this study, we develop laser direct writing technology to improve the emitted light polarization of ${\rm{CsPbClB}}{{\rm{r}}_2}$ quantum dot film.
Glued diffraction optical elements with broadband and a large field of view
Abstract High diffraction efficiency is an important requirement for hybrid diffractive-refractive optical systems with a wide field of view. The issue is that diffractive optical elements cannot maintain high diffraction efficiency across a designed waveband and range of incident angles simultaneously. Glued diffractive optical elements (GDOEs) consist of two single-layer diffractive elements, and optical adhesives are presented to address the problem.
The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level
Highlights • dSox9/Sox100B promotes ISC proliferation only at an appropriate level • Sox100B is directly induced by both JAK/STAT and EGFR/Ras signaling pathways • Sox100B overexpression inhibits MAPK signaling by suppressing EGFR expression • Sox100B promotes cell differentiation via a Sox100B-Sox21a-Pdm1 regulatory circuitry Summary Balanced stem cell self-renewal and differentiation is essential for maintaining tissue homeostasis, but the underlying mechanisms are poorly understood.
Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation
Research Article | Host-Microbe Biology Yan-Heng Zhou, Li Sun, Jun Chen, Wei-Wei Sun, Li Ma, Yang Han, Xia Jin, Qing-Xia Zhao, Taisheng Li, Hongzhou Lu, Xiu Qiu, Jian-Hua Wang Matthew S. Miller, Editor DOI: 10.1128/mBio.02591-19 ABSTRACT Multiple cellular metabolic pathways are altered by HIV-1 infection, with an impact on immune activation, inflammation, and acquisition of non-AIDS comorbid diseases.
Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo
Highlights • Spatial transcriptome collated from RNA-seq data of the epiblast of mouse gastrula • Rendition of expression pattern of 20,000 genes as digital whole-mount and corn plot • Domains of transcription and signaling activity correlate with epiblast cell fates • Mapping cell identity and home address in the epiblast by zip code marker genes Summary Gastrulation of the mouse embryo entails progressive restriction of lineage potency and the organization of the lineage progenitors into a...
Visual Chemical Detection Mechanism by a Liquid Gating System with Dipole‐Induced Interfacial Molecular Reconfiguration
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Communication Visual Chemical Detection Mechanism by a Liquid Gating System with Dipole‐Induced Interfacial Molecular Reconfiguration Yi Fan State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005 P. R. China These authors contributed equally to this work.
Testing in Microbiome-Profiling Studies with MiRKAT, the Microbiome Regression-Based Kernel Association Test
High-throughput sequencing technology has enabled population-based studies of the role of the human microbiome in disease etiology and exposure response. Distance-based analysis is a popular strategy for evaluating the overall association between microbiome diversity and outcome, wherein the phylogenetic distance between individuals’ microbiome profiles is computed and tested for association via permutation.
Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
We coexist with our gut microbiota as mutualists, but this relationship sometimes becomes pathological, as in obesity, diabetes, atherosclerosis, and inflammatory bowel diseases (1, 2). Factors including age, genetics, and diet may influence microbiome composition (3). Of these, diet is easiest to modify and presents the simplest route for therapeutic intervention.
Laser direct-writing electrode for rapid customization of a photodetector
Abstract The interdigital Ag electrode is fabricated via a simple and fast approach called laser direct writing (LDW). The morphology and conductivity of electrode fingers are investigated systematically under different experimental parameters, including the laser spot size, laser power, and scanning speed. “Dose” describes the combined influence of these experimental parameters.
Potential use of peanut by-products in food processing: a review
Xiaoyan Zhao, Jun Chen, and Fangling Du Xiaoyan Zhao Institute Agro-Food Science & Technology, Shandong Academy of Agricultural Sciences, No. 202, Gongyebei Road, Jinan, 250100 China Jun Chen Institute Agro-Food Science & Technology, Shandong Academy of Agricultural Sciences, No. 202, Gongyebei Road, Jinan, 250100 China Fangling Du Institute Agro-Food Science & Technology, Shandong Academy of Agricultural Sciences, No. 202, Gongyebei Road, Jinan, 250100 China Author information Article notes...
Discrimination of incoherent vortex states of light
Coherence vortex (CV) states provide a new way for optical manipulation and communication. As a promising option for increasing the data-transmission capacity, CV multiplexing warrants investigation. However, few studies have focused on discriminating and sorting CV states with different topological charges. In this work, we examine the cross-spectral density (CSD) of a CV state embedded in an incoherent light field and so-called incoherent vortex (ICV).
Sensitivity of displacement detection for a particle levitated in the doughnut beam
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Genomic data provides new insights on the demographic history and the extent of recent material transfers in Norway spruce
Genomic data provides new insights on the demographic history and the extent of recent material transfers in Norway spruce Jun Chen, lili li, Pascal Milesi, Gunnar Jansson, Mats Berlin, Bo Karlsson, Jelena Aleksic, Giovanni G Vendramin, Martin Lascoux bioRxiv 402016; doi: https://doi.org/10.1101/402016
Systematic Bias Introduced by Genomic DNA Template Dilution in 16S rRNA Gene-Targeted Microbiota Profiling in Human Stool Homogenates
ABSTRACTVariability in representation of microbial communities can be caused by differences in microbial composition or artifacts introduced at sample collection or processing. Alterations in community representation introduced by variations in starting DNA concentrations have not been systematically investigated in stool samples.
SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy
Highlights Blockade of the SIRPα–CD47 innate immune checkpoint shows promise as a new way to treat cancer. Accumulating data suggest that SIRPα–CD47 blockade per se may not be sufficient to trigger phagocytosis of tumor cells. Engagement of prophagocytic receptors such as Fc receptors or SLAMF7 is also needed. The impact of SIRPα–CD47 blockade may be further improved by relieving additional constraints on phagocytosis.
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