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Articles by Jun Hata
Retinal reflectance spectra measured using hyperspectral imaging are associated with prevalent dementia in a general older Japanese population
Abstract Advances in retinal hyperspectral imaging demonstrate its potential usefulness in neurodegenerative disorders; however, community-based evidence is lacking. We examined associations between retinal reflectance spectra and prevalent dementia in 857 Hisayama Study residents aged ≥ 65 years who underwent eye and dementia examinations in 2022–2023.
Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population - npj Genomic Medicine
Abstract The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47).
Plasma biomarkers for predicting the development of dementia in a community‐dwelling older Japanese population
Lecanemab was recently given full approval from the US Food and Drug Administration as a disease-modifying drug for Alzheimer disease (AD),1 creating an urgent need for the identification of minimally invasive, low-cost, and time-effective tools for screening and risk stratification of patients with any level of cognitive decline.
Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study
Abstract Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer.
Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia
Glossary 3D-T1WI= 3-dimensional T1-weighted image; BDNF= brain-derived neurotrophic factor; BMI= body mass index; eGFR= estimated glomerular filtration rate; FDR= false discovery rate; GDS= Geriatric Depression Scale; HbA1c= hemoglobin A1c; ICV= intracranial volume; JPSC-AD= Japan Prospective Studies Collaboration for Aging and Dementia; MCI= mild cognitive impairment; MMSE= Mini-Mental State Examination; TBV= total brain volume; WMLV= white matter lesion volume Footnotes Go to...
Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia: The JPSC-AD Study
REQUIREMENTS You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information. Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
Epidemiology of Stroke in a General Japanese Population: The Hisayama Study
Skip to main page content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software doi: 10.5551/jat.RV22004. Online ahead of print.
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries - Nature
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Author notes These authors contributed equally: Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner These authors jointly supervised this work: Christian T. Ruff, Mayowa O. Owolabi, Jennifer E.
By Aniket Mishra Verified, Tsuyoshi Hachiya, Shinichi Namba, Daniel Posner, Frederick K. Kamanu, Masaru Koido, Quentin Le Grand, Yunye He, Marios K. Georgakis, Ilana Caro, Kristi Krebs, Yi-Ching Liaw, Felix C. Vaura, Bendik Slagsvold Winsvold, Liisa Tomppo, Gennady V Roshchupkin, Naomi Habib, Jesper Qvist Thomassen, Vida Abedi, Marianne Nygaard, Hampton L. Leonard, Maria J. Knol, Philippe Amouyel, Mark Bakker, Joshua C. Bis, Constance Bordes, Sigrid Børte, Zhengming Chen, Rafael de Cid, Matthias Endres, Leslie E. Ferreira, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Alicia K Heath, Aki S Havulinna, Michael Inouye, Christina E. Jeon, Keith L. Keene, Amit Kumar, Paul Lacaze, Lenore J. Launer, Kaido Lepik, Jiang Li, Ani W Manichaikul, Felipe A. Montellano, Børge G Nordestgaard, Yukinori Okada, Annette Peters, Bruce M. Psaty, Stephen S. Rich, Danish Saleheen, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L. Satizabal, Atsushi Shimizu, Yan Sun, Kozo Tanno, Steffen Tiedt, Stella Trompet, Marion van Vugt, Riina Vibo, Kerri L. Wiggins, Huichun Xu, Qiong Yang, Kyungheon Yoon, Christian Gieger, Toshiharu Ninomiya, J. Wouter Jukema, young kim, Ernst Mayerhofer, Joanna M. M. Howson, Hieab H. Adams, Sylvia Wassertheil-Smoller, Kaare Christensen, Mohammad A. Ikram, Tatjana Rundek, Bradford B. Worrall, Janika Kõrv, Ruth Frikke-Schmidt, Karl Georg Haeusler, Peter Heuschmann, Guillaume Pare, Daniel I. Chasman, Teemu J. Niiranen, Myriam Fornage, Sudha Seshadri, Robin G Walters, Mayowa Owolabi, Jennifer Huffman Verified, Lili Milani, Martin Dichgans
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Nature
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Stroke genetics informs drug discovery and risk prediction across ancestries - Nature
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Abstract Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2.
By Aniket Mishra Verified, Tsuyoshi Hachiya, Shinichi Namba, Daniel Posner, Frederick K. Kamanu, Masaru Koido, Marios K. Georgakis, Kristi Krebs, Bendik Slagsvold Winsvold, Liisa Tomppo, Gennady V Roshchupkin, Naomi Habib, Vida Abedi, Marianne Nygaard, Hampton L. Leonard, Maria J. Knol, Philippe Amouyel, Mark Bakker, Joshua C. Bis, Sigrid Børte, Zhengming Chen, Rafael de Cid, Matthias Endres, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Alicia K Heath, Aki S Havulinna, Michael Inouye, Keith L. Keene, Amit Kumar, Paul Lacaze, Lenore J. Launer, Kaido Lepik, Jiang Li, Ani W Manichaikul, Børge G Nordestgaard, Yukinori Okada, Annette Peters, Bruce M. Psaty, Stephen S. Rich, Danish Saleheen, Veikko Salomaa, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia L. Satizabal, Atsushi Shimizu, Yan Sun, Kozo Tanno, Steffen Tiedt, Stella Trompet, Kerri L. Wiggins, Huichun Xu, Qiong Yang, Christian Gieger, Toshiharu Ninomiya, J. Wouter Jukema, young kim, Ernst Mayerhofer, Joanna M. M. Howson, Hieab H. Adams, Sylvia Wassertheil-Smoller, Kaare Christensen, Mohammad A. Ikram, Tatjana Rundek, Bradford B. Worrall, Janika Kõrv, Ruth Frikke-Schmidt, Karl Georg Haeusler, Peter Heuschmann, Guillaume Pare, Daniel I. Chasman, Teemu J. Niiranen, Myriam Fornage, Sudha Seshadri, Robin G Walters, Mayowa Owolabi, Jennifer Huffman Verified, Lili Milani, Martin Dichgans, Quentin Le Grand, Yunye He, Ilana Caro, Yi-Ching Liaw, Felix C. Vaura, Jesper Qvist Thomassen, Constance Bordes, Leslie E. Ferreira, Christina E. Jeon, Felipe A. Montellano, Marion van Vugt, Riina Vibo, Kyungheon Yoon
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Nature
Verified
Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan
Abstract Objective To estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. Methods A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed up prospectively for 17 years.
30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study
Epidemiology/Health Services Research 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study http://orcid.org/0000-0002-4405-4399Yoichiro Hirakawa1,2, Jun Hata1,3, Masahito Yoshinari1,2, Mayu Higashioka1, Daigo Yoshida1, Mao Shibata3, Takanori Honda1, Satoko Sakata3, Hiroyuki Kato4, Takanori Teramoto4, Hideki Maki4, Shozo Nishimoto4, Takanari Kitazono2,3, http://orcid.org/0000-0003-1345-9032Toshiharu...
Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: The Hisayama study
Highlights • The risk of incident AF increased with higher serum NT-proBNP levels. • Incorporation of serum NT-proBNP improved the predictive ability for incident AF. • Serum NT-proBNP may be a useful biomarker for evaluating future risk of AF. Abstract Background Biomarkers for predicting future development of atrial fibrillation (AF) have not been fully established in general populations.
Serum homocysteine and risk of dementia in Japan
Serum homocysteine and risk of dementia in Japan http://orcid.org/0000-0003-0811-1701Sanmei Chen1, http://orcid.org/0000-0002-1011-9879Takanori Honda1, Tomoyuki Ohara1,2, Jun Hata1,3,4, Yoichiro Hirakawa1,4, Daigo Yoshida1, Mao Shibata1,3, Satoko Sakata1,3,4, Emi Oishi1,4, Yoshihiko Furuta1,4, Takanari Kitazono3,4, Toshiharu Ninomiya1,3 1Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Neuropsychiatry, Graduate...
Serum elaidic acid concentration and risk of dementia
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Serum soluble TREM2 as a biomarker for incident dementia: the Hisayama Study
Objective To investigate the association between serum soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a soluble type of an innate immune receptor expressed on the microglia, and the risk of dementia. Methods A total of 1,349 Japanese community‐residents aged 60 and older without dementia were followed prospectively for 10 years (2002‐2012). Serum sTREM2 levels were quantified by using an enzyme‐linked immunosorbent assay and divided into quartiles.
A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama Study
Publication HistoryPublished online: October 16, 2018Accepted: October 11, 2018; Received in revised form: October 1, 2018; Received: May 16, 2018;
Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke
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Dietary Protein Intake and Stroke Risk in a General Japanese Population
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Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study
Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Gotoh, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya Diabetes Care Sep 2016, 39 (9) 1543-1549; DOI: 10.2337/dc15-2800
Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke
Background and Purpose—The relationship between blood pressure (BP) variability and functional outcome in patients with acute ischemic stroke remains unclear. This study aimed to elucidate whether in-hospital day-by-day BP variability is associated with functional outcome after acute ischemic stroke. Methods—Using the Fukuoka Stroke Registry, we included 2566 patients with a first-ever ischemic stroke who had been functionally independent before the onset and were hospitalized within 24 hours.
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