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Articles by Junchen Li
Tyrosine hydroxylase/catecholamine signaling pathway promotes high-risk neuroblastoma growth by upregulating MYCN
Abstract Neuroblastoma (NB) is an aggressive pediatric cancer with poor high‑risk prognosis. MYCN amplification (MNA) is an established high-risk biomarker but is present in only approximately 20% of patients. Consistent with recent studies, our results showed that high MYCN expression, observed in approximately 60% of high-risk patients, serves as a more prevalent biomarker for high-risk NB, although its upstream regulatory mechanism remains incompletely understood.
A quantum-informed gradient catalyst layer architecture for freeze-resistant proton exchange membrane fuel cell cold startup via DFT guided machine learning
Abstract Cold start represents a critical barrier to automotive PEMFC commercialization, as product water from the oxygen reduction reaction freezes rapidly at sub-zero temperatures, blocking catalyst active sites and transport pathways. This work proposes a quantum-mechanically guided hydrophilic-hydrophobic gradient catalyst layer architecture optimized for freeze-resistant cold startup at − 20 °C.
Knowledge, attitudes, and practices of patients and family members regarding the use of susceptibility-weighted imaging-based optimized substantia nigra imaging in Parkinson’s diagnosis
Abstract This study evaluated the knowledge, attitudes, and practices (KAP) regarding susceptibility-weighted imaging-based optimized substantia nigra (SN-SWI) among patients with Parkinson’s disease (PD) and family members in Suzhou, China. A cross-sectional survey was conducted between April 1, 2024, and March 1, 2025, across three hospitals in Suzhou. The questionnaire captured demographic characteristics and KAP scores. Of the 501 valid responses, 71.86% of participants were aged ≤ 60 years.
Lipid metabolic reprogramming in osteoarthritis: cartilage-centered mechanisms, whole-joint interactions, and therapeutic challenges
Abstract Osteoarthritis (OA) is a biologically heterogeneous whole-joint disorder characterized by cartilage damage, synovitis, subchondral bone remodeling, pain, and progressive functional decline. Although OA has long been viewed primarily as a mechanically driven disorder, clinical and experimental evidence indicates that lipid metabolic dysregulation contributes to OA susceptibility, symptom burden, and disease progression in at least a subset of patients.
Achieving high strength in 430 stainless steel by laser powder bed fusion: microstructure-property relationships and strengthening strategies
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACT Conventional manufacturing of 430 ferritic stainless steel faces significant challenges, including severe work hardening, rapid tool wear, and limited strengthening via heat treatment.
Stereoselective Synthesis of α-Aminophosphonates and Their Derivatives via Asymmetric α-Azidation of the CAMDOL-Derived Phosphonates
Cite Jump to ExpandCollapse LetterSeptember 8, 2025 Stereoselective Synthesis of α-Aminophosphonates and Their Derivatives via Asymmetric α-Azidation of the CAMDOL-Derived Phosphonates Click to copy article linkArticle link copied! Yu Huang Yu Huang State Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China Qian Wu Qian Wu State Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China Junchen Li Junchen Li State Key Laboratory of Chemistry for NBC...
Microstructural Response in Friction Stir Additive Manufacturing of 5A06 Aluminum Alloy
1. Introduction Additive manufacturing (AM), also known as three-dimensional (3D) printing, offers several advantages across a range of industries, from the aerospace and automotive industries to those responsible for healthcare and consumer products [1,2]. AM offers many advantages such as design freedom, material efficiency, faster time-to-market, reduced waste, opportunities to recycle materials, and the ability to produce customized parts [3,4,5,6].
DCSSM: Enhancing Medical Organ Segmentation with Positional Correlation and Feature Alignment
You are already at the latest version Medical organ segmentation is essential for accurately identifying the underlying causes of diseases and developing appropriate treatment plans. Current distribution methods primarily focus on the segmentation task, often neglecting the relationship between image distribution and segmentation. Effective image distribution aligns features and can also serve as a boundary constraint in the segmentation task.
Adjustable and Low-Cost Production of Magnesium Alloys Using a Liquid Metal Cathode
Adjustable and Low-Cost Production of Magnesium Alloys Using a Liquid Metal Cathode Magnesium (Mg) alloys are known for their exceptional properties and versatile applications but suffer from inherent challenges in production including complex processes, high energy consumption, limited alloy tunability, and costly electrolytes.
Lysosomes, Curcumin, and Anti-Tumor Effects: How Are They Linked?
Abstract Curcumin is a natural active ingredient from traditional Chinese medicine (TCM) that has multi-target characteristics to exert extensive pharmacological activities and thus has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders.
Emerging Current Trends and Research Focus Related to Pancreatic Cancer Metabolism: A Bibliometric and Visualized Analysis
BACKGROUND: As a malignant digestive system tumor, pancreatic cancer has unique metabolic characteristics. In recent years, the study of pancreatic cancer metabolism is in full swing, which provides a new direction for the treatment of pancreatic cancer patients. However, there is no systematic report of pancreatic cancer metabolism.
Effect of Rotational Velocity on Mechanical and Corrosion Properties of Friction Stir-Welded SUS301L Stainless Steel
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates
1. Introduction As a kind of privileged scaffold, imidazo[1,2-α]pyridines are often used as the pharmacodynamic backbones of versatile drugs, such as anti-ulcer [1], anti-inflammatory [2], anti-viral [3,4], anti-bacterial [5], anti-cancer [6], anti-HIV [7] and anti-tuberculosis pharmaceutical candidates [8].
Copper-Catalyzed Azide-Alkyne Cycloaddition-Oriented Multifunctional Bio-Orthogonal Linker BPPA: Design, Synthesis and Evaluation
1. Introduction Dynamically investigating the life processes of biomolecules in the natural environment with chemical methods has always attracted significant attention. However, it is difficult to find chemical reactions with good biocompatibility and high selectivity under physiological conditions or in cells of living organisms due to the vast complexity of biological systems [1].
Dual functionalization of O and S in Zr2N facilitates efficient storage of lithium ions by first-principles calculation
Dual functionalization of O and S in Zr2N facilitates efficient storage of lithium ions by first-principles calculation This paper constructs a single O and S functionalized Zr2N model for surface levelling and sametime a series of bifunctional models with different functional group ratios and distributions.
First principles calculations of the electronic configuration and photocatalytic performance of GaSe(Ga2SSe)/MoS2(MoSSe) heterojunctions
First principles calculations of the electronic configuration and photocatalytic performance of GaSe(Ga2SSe)/MoS2(MoSSe) heterojunctions The electronic structure and photocatalytic performance of GaSe/MoSSe and Ga2SSe/MoS2 heterojunctions are systematically investigated by means of first-principles calculations.
Pan-cancer analysis and experimental validation identify ndc1 as a potential immunological, prognostic and therapeutic biomarker in pancreatic cancer
Research Paper Volume 15, Issue 18 pp 9779—9796 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China 2 Tianjin University of Traditional Chinese Medicine, Tianjin, China * Equal contribution https://doi.org/10.18632/aging.205048 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2023 Shen et al.
Pan-cancer analysis and experimental validation identify ndc1 as a potential immunological, prognostic and therapeutic biomarker in pancreatic cancer
Research Paper Volume 15, Issue 18 pp 9779—9796 1 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China 2 Tianjin University of Traditional Chinese Medicine, Tianjin, China * Equal contribution https://doi.org/10.18632/aging.205048 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | This is an open access article distributed under the terms of the...
Hot Deformation Behavior of 301L Stainless Steel and Dissolution Behavior of δ‐Ferrite during Heat Treatment
Abstract The hot deformation behavior of 301L stainless steel is investigated at 1000∽1250°C and 0.1∽50s-1. Deformation characteristics are studied through compressive stress-strain curves and constitutive equations. According to the dynamic material model and a series of diffusion annealing experiments, the hot processing map of 301L stainless steel was established to determine the suitable processing domain.
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