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Articles by Junwei Hao
Tenecteplase for Acute Non–Large Vessel Occlusion After Ischemic Stroke—Reply
In Reply We thank Dr Morelli and colleagues for their thoughtful comments about the OPTION trial.1 Regarding the concern that mild baseline neurological deficits might influence favorable outcomes (mRS score range, 0-1), randomization successfully balanced patients with NIHSS scores of less than 6 between the 2 groups (90 with tenecteplase vs 92 controls).
Multimodal clocks of human aging
Letters to the Editor
Steven L. Galetta, MD, FAAN, Editor Aravind Ganesh, MD, DPhil, Deputy Editor Ariane Lewis, MD, Deputy Editor James E. Siegler III, MD, Deputy Editor Join the Conversation Whether you are a veteran neurology professional, resident, or fellow—you are encouraged to present your own findings, ask a question, or comment on methodology, results, or conclusions featured in recently published articles. Accepted letters are posted rapidly alongside published articles.
Platelet activation plays a pro-inflammatory role in myasthenia gravis - Nature Communications
Abstract Myasthenia gravis (MG) is an autoimmune disorder that disrupts neuromuscular junction function through autoantibodies. Platelets are emerging as key players in the pathogenesis of MG, bridging innate and adaptive immunity. We analyze platelet transcriptome signatures and their interactions with the immune system in AChR+ immunotherapy-naïve MG (nMG) patients using bulk and single-cell RNA sequencing on peripheral blood mononuclear cells (PBMC).
Micronutrient Biofortification in Wheat: QTLs, Candidate Genes and Molecular Mechanism
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SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice - Nature Communications
Abstract Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. The complex pathology of DACD remains unknown. Here, we performed single-nucleus RNA sequencing (snRNA-seq) to demonstrate unique cellular and molecular patterns of the hippocampus from a mouse model of diabetes.
Temperature-related death burden of various neurodegenerative diseases under climate warming: a nationwide modelling study - Nature Communications
Abstract Limited knowledge exists regarding the ramifications of climate warming on death burden from neurodegenerative diseases. Here, we conducted a nationwide, individual-level, case-crossover study between 2013 and 2019 to investigate the effects of non-optimal temperatures on various neurodegenerative diseases and to predict the potential death burden under different climate change scenarios.
The clinical features of combined central and peripheral demyelination and antibodies against the node of Ranvier
1. Thomas, PK, Walker, RW, Rudge, P, et al. Chronic demyelinating peripheral neuropathy associated with multifocal central nervous system demyelination. Brain 1987; 110(1): 53–76. Google Scholar | Crossref | Medline 2. Zephir, H, Stojkovic, T, Latour, P, et al. Relapsing demyelinating disease affecting both the central and peripheral nervous systems. J Neurol Neurosurg Psychiatry 2008; 79(9): 1032–1039. Google Scholar | Crossref | Medline 3. Kawamura, N, Yamasaki, R, Yonekawa, T, et al.
High Performance of Sulfur/Carbon Cathode Synthesized via a Facile Green Microwave Approach
Sulfur has a specific capacity of 1675 mAh·g–1 as a lithium battery cathode, but its rapid capacity decay due to the migration of dissolved polysulfides presents a major challenge for commercialization. Most approaches in the past few decades have focused on impregnating sulfur into a carbon host via various harsh, time-consuming, and costly carbonization techniques. In this context, sublimed sulfur is introduced into a commercial carbon via microwave treatment in minutes for the first time.
Double-negative T cells remarkably promote neuroinflammation after ischemic stroke
Significance In the present study, we found a significantly up-regulated CD3+CD4−CD8− T cell (double-negative T cell; DNT) population in the peripheral blood of patients with acute stroke compared with age-matched healthy subjects. Interestingly, infiltrating DNTs were mainly located close to microglia in the ischemic brain tissues of both stroke patients and middle cerebral artery occlusion mice.
Selective Sphingosine-1-Phosphate Receptor 1 Modulation Attenuates Experimental Intracerebral Hemorrhage
Background and Purpose—Preclinical studies and a proof-of-concept clinical study have shown that sphingosine-1-phosphate receptor (S1PR) modulator, fingolimod, improves the clinical outcome of intracerebral hemorrhage (ICH). However, the specific subtype of the S1PRs through which immune modulation provides protection in ICH remains unclear.
Fingolimod for the Treatment of Intracerebral Hemorrhage: A 2-Arm Proof-of-Concept Study
Importance Pronounced inflammatory reactions occurring shortly after intracerebral hemorrhage (ICH) contribute to the formation and progression of perihematomal edema (PHE) and secondary brain injury. We hypothesized that modulation of brain inflammation reduces edema, thus improving clinical outcomes in patients with ICH.
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