Junying Liu
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The lipotoxicity–ferroptosis axis in the transition from insulin resistance to type 2 diabetes: mechanistic integration and therapeutic opportunities
Abstract Insulin resistance is an early feature of type 2 diabetes mellitus (T2DM), but progression to persistent hyperglycemia requires failure of pancreatic β-cell compensation. Lipotoxicity develops when adipose storage and oxidative capacity are exceeded, increasing fatty-acid flux and accumulation of ceramides, diacylglycerols, and oxidizable phospholipids in liver, skeletal muscle, and pancreatic islets.
Preliminary Evaluation of Leuprorelin Acetate Microspheres Plus Levonorgestrel-Releasing Intrauterine System in Endometriosis: An Exploratory Study Focusing on BNIP3 and EPAC1 Expression
Disclosure The article was not presented in abstract form at a conference or as part of a presentation. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement We are unable to share data because of the ethical requirement of our institution to prevent harm and promote fairness that benefited the enrolled subjects. References 1, , and , “Diagnosis and Management of Endometriosis,” CMAJ 195, no. 10 (2023): E363–e371.
Genome-wide identification, evolutionary dynamics, and abiotic stress response networks of the magnesium transporter gene family in foxtail millet ( Setaria italica L.)
Abstract Magnesium (Mg²+) is an essential mineral nutrient for plant growth, playing a pivotal role in chlorophyll biosynthesis, enzyme activation, photosynthesis, and ion homeostasis. The magnesium transporters (MGTs) from the CorA/MRS2-ALR superfamily are crucial for Mg²+ uptake, translocation, and subcellular compartmentalization.
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