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Justin Savage

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Articles

ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis

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By Sarah van Veen, Dolores Irala, Kristina Sakers, Zhaolin Liu, Justin Savage, Gabrielle Sejourne, Dhanesh Sivadasan Bindu, Elke Ausloos, Joris Van Asselberghs, Keimpe Wierda, Veerle Baekelandt, Konrad Platzer, Kevin Rostásy, Kai Lee Yap, Matthew Holt, Cagla Eroglu, Peter Vangheluwe, Emily Meeus, Hanna Elzbieta Grzesik, Hanne Dhondt, Nina Schoonvliet, Chris Van den Haute, Marta Montpeyó Garcia-Moreno, Jan Eggermont
| Nature Verified
Abstract Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in astrocytes, governs brain polyamine balance. Using biochemical, cellular, and animal models, we find that ATP13A4 imports polyamines into cells and thereby limits their availability outside cells.
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U.S. EPA Issues Latest Proposal to Amend the Risk Management Program: A Return to Regulatory Stability?

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By Justin Savage
| Accelerating Energy: Powering Business Through the Energy Transition
In an article published in Pratt’s Energy Law Report, Sidley lawyers Justin Savage, Timothy Webster, Brittany Bolen, Rose Quam-Wickham and Jeffrey Davis examine the U.S. Environmental Protection Agency’s (EPA) latest proposal to amend the Clean Air Act Risk Management Program (RMP) regulations.
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Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement

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By Juan Ramirez, Juan Ramírez, Evelyn J. Hardin, Kristina Sakers, Jinhu Kim, Crystal Ortiz, Justin Savage, Richa Hanamsagar, Sandeep Singh Verified, Staci D. Bilbo, Cagla Eroglu
| Cell Press Verified
ArticleOnline nowOpen access Affiliations & Notes 1Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA 2Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA 3Howard Hughes Medical Institute, Duke University, Durham, NC 27710, USA 4Department of Psychology and Neuroscience, Duke University, Durham, NC 27710, USA 5Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA...
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