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Abstract Efficient priming of B cell precursors is a rate-limiting step in the induction of V2 apex broadly neutralizing antibodies (bNAbs)1,2. Here, we describe a novel germline-targeted HIV-1 Env (CAP256.OPT4) that increases the efficiency of V2 apex bNAb precursor priming by 30-400 fold compared with wild-type HIV-1 Envs and induces – in >90% of macaques – neutralization breadth that includes N130-containing viruses.
ArticleVolume 7, Issue 2102611Open access Affiliations & Notes 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 3Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 4Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA...
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