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Barton F. Haynes on Muck Rack

Barton F. Haynes

As seen in: Nature, Wiley Online Library, Flipboard, The New England Journal of Medicine, Science Magazine, Cell Press, The Journal of Clinical Investigation
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Articles

Antibodies against HLA-E–VL9 enhance NK cell and CD8 + T cell cytotoxicity against tumor cells and HIV-infected CD4 + T cells

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By Minwoo Kim, Zaofeng Yang, Liang Ma, Joyce K. Hwang, Marina Tuyishime, Daniel J. Marston, Hongbing Yang, Daniel Wrapp, Dapeng Li, Simon Brackenridge, McKenzie Frazier, Richard Scearce, Brianna Rhodes, Caitlin Harris, Max Quastel, Anyway Kapingidza, Anna E. Kliszczak, Persephone Borrow, Guido Ferrari, Geraldine M. Gillespie, Andrew J. McMichael, Barton F. Haynes, Nicholas P. Levering, Jacob Gater, Mihai L. Azoitei
| Science Magazine Verified
Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract A major natural killer (NK) cell and CD8+ T cell checkpoint is mediated by the inhibitory receptor NKG2A/CD94 and its ligand, human leukocyte antigen E (HLA-E) complexed with nine–amino acid HLA-Ia leader sequence-derived peptides termed VL9 (HLA-E–VL9).
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Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies

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By Lorie Marchitto, Kshitij Wagh, Ryan Roark, Séverin Coléon, Hui Li, Ashwin N. Skelly, Michael P. Hogarty, Rumi Habib, Wenge Ding, Kasirajan Ayyanathan, Weimin Liu, Zizhang Sheng, Yicheng Guo, Lena Smith, Laura Sutherland, Younghoon Park, Andrew Connell, Frederic Bibollet-Ruche, Emily Lewis, Samantha Plante, Macy J. Akeley, Chengyan Zhao, John Carey, Christian Martella, Yingying Li, Mary S. Campion, Rebecca A. Osbaldeston, Colette G. Gordon, Amie Albertus, Justin Su, Chiaki Noguchi, Ying Tam, Christopher Barbosa, Xuduo Li, Agnes Walsh, Darrell J. Irvine, Raiees Andrabi, Robert Edwards, Edward F. Kreider, Drew Weissman, Lawrence Shapiro, Peter D. Kwong, Bette Korber, Barton F. Haynes, Kevin Saunders, Beatrice H. Hahn, George Shaw, Joena Bal, Jinery Lora, Melinda G. Lituchy, Khaled Amereh
| Nature Verified
Abstract Efficient priming of B cell precursors is a rate-limiting step in the induction of V2 apex broadly neutralizing antibodies (bNAbs)1,2. Here, we describe a novel germline-targeted HIV-1 Env (CAP256.OPT4) that increases the efficiency of V2 apex bNAb precursor priming by 30-400 fold compared with wild-type HIV-1 Envs and induces – in >90% of macaques – neutralization breadth that includes N130-containing viruses.
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Mechanistic and antigenic boundaries of Henipavirus and Parahenipavirus glycoproteins

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By Aaron May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Kejun Liu, Moumita Dutta, Maggie Barr, Rob Parks Verified, Xiaozhi Lu, Madison Berry, Amanda Powell, Amelia Thompson, Sravya Sowdamini Nakka, Camila T. França, Xiao Huang, Arpita Mrigwani, Kijun Song, Salam Sammour, Chan Soo Park, Radha Adhikari, Katarzyna Janowska, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Kevin Wiehe, Nancy Sullivan, Rosemarie Mason, Robert Edwards, Kevin Saunders, Barton F. Haynes, Priyamvada Acharya, Victor Ilevbare, Priyanka Devkota, Yanshun Liu
| Nature Verified
Abstract Henipaviruses, in the Paramyxoviridae family, includes the highly virulent Nipah virus that causes reoccurring outbreaks of deadly disease. Recent discoveries of Henipavirus-like species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized and prompted the reorganization of these viruses into the Henipavirus and Parahenipavirus genera.
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