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Barton F. Haynes on Muck Rack

Barton F. Haynes

As seen in: Nature, Wiley Online Library, Flipboard, Science Magazine, The New England Journal of Medicine, Cell Press, The Journal of Clinical Investigation
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Articles

Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies

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By Lorie Marchitto, Kshitij Wagh, Ryan Roark, Séverin Coléon, Hui Li, Ashwin N. Skelly, Michael P. Hogarty, Rumi Habib, Wenge Ding, Kasirajan Ayyanathan, Weimin Liu, Zizhang Sheng, Yicheng Guo, Lena Smith, Laura Sutherland, Younghoon Park, Andrew Connell, Frederic Bibollet-Ruche, Emily Lewis, Samantha Plante, Macy J. Akeley, Chengyan Zhao, John Carey, Christian Martella, Yingying Li, Mary S. Campion, Rebecca A. Osbaldeston, Colette G. Gordon, Amie Albertus, Justin Su, Chiaki Noguchi, Ying Tam, Christopher Barbosa, Xuduo Li, Agnes Walsh, Darrell J. Irvine, Raiees Andrabi, Robert Edwards, Edward F. Kreider, Drew Weissman, Lawrence Shapiro, Peter D. Kwong, Bette Korber, Barton F. Haynes, Kevin Saunders, Beatrice H. Hahn, George Shaw, Joena Bal, Jinery Lora, Melinda G. Lituchy, Khaled Amereh
| Nature Verified
Abstract Efficient priming of B cell precursors is a rate-limiting step in the induction of V2 apex broadly neutralizing antibodies (bNAbs)1,2. Here, we describe a novel germline-targeted HIV-1 Env (CAP256.OPT4) that increases the efficiency of V2 apex bNAb precursor priming by 30-400 fold compared with wild-type HIV-1 Envs and induces – in >90% of macaques – neutralization breadth that includes N130-containing viruses.
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Mechanistic and antigenic boundaries of Henipavirus and Parahenipavirus glycoproteins

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By Aaron May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Kejun Liu, Moumita Dutta, Maggie Barr, Rob Parks Verified, Xiaozhi Lu, Madison Berry, Amanda Powell, Amelia Thompson, Sravya Sowdamini Nakka, Camila T. França, Xiao Huang, Arpita Mrigwani, Kijun Song, Salam Sammour, Chan Soo Park, Radha Adhikari, Katarzyna Janowska, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Kevin Wiehe, Nancy Sullivan, Rosemarie Mason, Robert Edwards, Kevin Saunders, Barton F. Haynes, Priyamvada Acharya, Victor Ilevbare, Priyanka Devkota, Yanshun Liu
| Nature Verified
Abstract Henipaviruses, in the Paramyxoviridae family, includes the highly virulent Nipah virus that causes reoccurring outbreaks of deadly disease. Recent discoveries of Henipavirus-like species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized and prompted the reorganization of these viruses into the Henipavirus and Parahenipavirus genera.
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A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain - Communications Biology

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By Kevin Saunders, Robert Edwards, Barton F. Haynes, Derek Cain
| Nature Verified
Abstract HCoV-229E is an endemic Alphacoronavirus that typically causes common cold-like disease in most healthy adults, but can also cause severe respiratory disease in the very young and the elderly. Although the virus was discovered over sixty years ago and undergoes continuous antigenic drift, remarkably little is known about the humoral immune response to HCoV-229E infection.
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