Kabsoo Shin

Abstract Breast cancer remains a major global health challenge1. Here, to comprehensively characterize its genomic landscape and the clinical significance of genomic characteristics, we analysed whole-genome sequences from 1,364 clinically annotated breast cancers, with transcriptome data available for most cases. Our study expands the repertoire of oncogenic alterations and identifies novel driver genes, recurrent gene fusions, structural variants and copy number alterations.

Discussion Traditionally, patients with solitary or large brain metastases have undergone surgical resection, but surgery alone results in a high local recurrence rate. To address this, postoperative WBRT has been commonly used, though it is associated with significant cognitive side effects (1-3, 11). With advancements in technology, postoperative SRS has emerged as an alternative, aiming to reduce cognitive decline while delivering higher doses to the surgical cavity (4, 5).

Abstract Advanced hepatocellular carcinoma (HCC) poses treatment challenges, especially where access to multi-kinase inhibitors and ICIs is limited by high costs and lack of insurance. This study evaluates the effectiveness of 5-fluorouracil (5-FU) plus platinum-based chemotherapy as an alternative systemic treatment for advanced HCC. A retrospective analysis of advanced HCC patients treated with 5-FU plus platinum-based chemotherapy was conducted.