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Articles by Kai Ge
KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis
Abstract Many craniofacial disorders linked to mutations in enhancer-associated chromatin modifiers, including Kabuki syndrome (KS), present with skeletal abnormalities. KS is a craniofacial developmental disorder characterized by mutations in KMT2D, a histone H3 lysine 4 (H3K4) methyltransferase. The cellular origins and molecular pathways leading to KMT2D-dependent skeletal deficits in KS are not well characterized.
Chromatin modifiers KMT2D, cBAF, and p300 cooperatively facilitate de novo binding of transcription factors on enhancers
Abstract Transcription factors (TFs) bind to enhancers and recruit H3K4me1 methyltransferase KMT2D, chromatin remodeler cBAF, and H3K27 acetyltransferase p300 to activate transcription. However, the role of chromatin modifiers in regulating de novo binding of TFs on enhancers remains unclear.
Warming of the subpolar North Pacific accelerated by sea ice retreat and wind changes
Abstract Climate models predict that the Pacific will become the foremost reservoir of human-induced heat in the 21st century among all oceans, with the subpolar North Pacific (SPNP) emerging as the critical region for heat uptake. Recent observations detect alarming warming rates across the Sea of Okhotsk, the Bering Sea, and the Gulf of Alaska. Yet, processes by which these seas absorb and store the heat remain unclear.
Increased heat transport of the Indonesian Throughflow linked to the spin-up of Southern-Hemisphere circulation gyres
Abstract Climate models project a weakening of the Indonesian Throughflow (ITF) under greenhouse warming. Here, using in-situ observations, we reveal an increase in the upper-700 m ITF heat transport into the Indian Ocean (IO) from 0.31 ± 0.05 PW during 1984–1997 to 0.57 ± 0.04 PW (1 PW = 1015 Watts) during 1998–2020.
Experimental Evaluation and xDLVO Modeling of Excipient Effects on Protein–Protein Interactions for High-Concentration Formulations
Cite Jump to ExpandCollapse ArticleMarch 2, 2026 Experimental Evaluation and xDLVO Modeling of Excipient Effects on Protein–Protein Interactions for High-Concentration Formulations Click to copy article linkArticle link copied! Kai Ge Kai Ge Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, P. R.
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism - Nature Communications
Abstract Skeletal muscle is a major organ for maintaining whole-body energy balance, yet how it adapts its transcriptional and metabolic programs to environmental cues remains unclear. Here, we report that histone mono-methyltransferase mixed lineage leukemia 4 (MLL4), a key enhancer regulator, directs muscle metabolic adaptation and systemic metabolism through AMPK signaling.
Potential value of cardiac troponin and pediatric Sequential Organ Fai
Back to Journals » International Journal of General Medicine » Volume 19 Original Research Cardiovascular Authors Zhu R, Ge K Received 16 September 2025 Accepted for publication 22 January 2026 Published 6 February 2026 Volume 2026:19 Pages 1—10 DOI https://doi.org/10.2147/IJGM.S562566 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Redoy Ranjan Rui Zhu, Kai Ge Department of Pediatrics, Shu Yang Hospital of TCM,...
Environmental Reconstruction of Undercoordinated 2D MOF Based Nickel for Efficient Urea Oxygen Reaction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202505346-sup-0001-SuppMat.docx2.6 MB Supporting Information References 1, , , , , , Chem. Soc. Rev. 2024, 53, 1552. 2, , , , , Angew. Chem., Int. Ed. 2025, 64, 202421027. 3, , , , , , Inorg. Chem. 2024, 63, 8925. 4, , , , , , Angew. Chem., Int. Ed. 2024, 137, 202417987. 5, , , , , , , Nat. Energy 2021, 6, 904. 6, , , , , , , Energ. Environ. Sci. 2018, 11, 1890. 7, , , , , , , Adv. Energy Mater.
S-Scheme Heterojunction Photocatalysts for CO2 Reduction
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In Situ Modulation of Oxygen Vacancies on 2D Metal Hydroxide Organic Frameworks for High‐Efficiency Oxygen Evolution Reaction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202311713-sup-0001-SuppMat.pdf2.6 MB Supporting Information References 1, , , , , , , , , , , , , , , Nat. Mater. 2023, 22, 100. 2, , , , , , , , , , Adv. Mater. 2022, 34, 2107488. 3, , , , , , , , Angew. Chem., Int. Ed. 2021, 60, 18821. 4, , , , , , , , , , , , , , , , , , , J. Am. Chem. Soc. 2022, 144, 2208. 5, , , , , , , , , , , Angew. Chem., Int. Ed. 2021, 60, 12097. 6, , , , , , , , , , Angew.
Surface Salinity Changes of the Tropical and Subtropical Oceans Since 1970 and Their Relationship With Surface Freshwater Fluxes
Supporting Information References , , , , & (2022). The ocean response to climate change guides both adaptation and mitigation efforts. Atmospheric and Oceanic Science Letters, 15(4), 100221. https://doi.org/10.1016/j.aosl.2022.100221 , & (2002). Constraints on future changes in climate and the hydrologic cycle. Nature, 419(6903), 224–232. https://doi.org/10.1038/nature01092 Argo. (2022). Argo float data and metadata from Global Data Assembly Centre. Argo GDAC.
Solubility Prediction and Dissolution Mechanism Analysis of Etodolac in Complex Polymer Solutions Based on Thermodynamic and Interfacial Mass Transfer Models
Download Hi-Res ImageDownload to MS-PowerPointCite This:Ind. Eng. Chem. Res. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Rotation Configuration Control of the sp2 Bond in Diimidazole−dicarboxylate Linker for Isomerism of Porous Coordination Polymers
Rotation Configuration Control of the sp2 Bond in Diimidazole−dicarboxylate Linker for Isomerism of Porous Coordination Polymers Jingui Duan, Qiubing Dong, Kai Ge, Mingxing Zhang and Huijie Wang Abstract Porous isomers that constructed from the same building blocks but different topology break the general preferred coordination rule of organic linkers and metal nodes, representing an invaluable opportunity for enriching the pore chemistry.
Heterostructured Ferroelectric BaTiO3@MOF-Fe/Co Electrocatalysts for Efficient Oxygen Evolution Reaction
Heterostructured Ferroelectric BaTiO3@MOF-Fe/Co Electrocatalysts for Efficient Oxygen Evolution Reaction Shuang Wang, Qiong Li, Shujuan Sun, Kai Ge, yi zhao, Kai Yang, zhiheng zhang, Jiayu Cao, Jie Lu, Yongfang Yang, Yue Zhang, Mingwang Pan, Zhiqun Lin and Lei Zhu Abstract Abstract The ability to substitute expensive and scarce noble metals with cheap and readily accessible nanomaterials represents an important endeavor toward water electrolysis to produce hydrogen, an alternative green fuel.
UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
Highlights • UTX promotes CD8+ T cell-mediated antiviral defenses • UTX increases inhibitory receptor expression and reduces T cell longevity • UTX does not require its H3K27me3 demethylase function to promote gene expression Summary Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist.
Facile Synthesis of Two‐Dimensional Iron/Cobalt Metal-Organic Framework for Efficient Oxygen Evolution Electrocatalysis
Research Article PDF ShareShare Abstract A facile synthesis is reported of two‐dimensional (2D) bimetallic (Fe/Co=1:2) metal–organic frameworks (MOF, ca. 2.2 nm thick) via simple stirring of the reaction mixture of Fe/Co salts and 1,4‐benzene dicarboxylic acid (1,4‐BDC) in the presence of triethylamine and water at room temperature. The mechanism of the 2D, rather than bulk, MOF was revealed by studying the role of each component in the reaction mixture.
Interplay of BAF and MLL4 promotes cell type-specific enhancer activation
Abstract Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF chromatin remodeling complex BAF and the histone H3K4 methyltransferase MLL4 (KMT2D) are both implicated in enhancer activation. However, the interplay between BAF and MLL4 in enhancer activation remains unclear.
Lysine Demethylase KDM6A in Differentiation, Development, and Cancer
Minireview Nhien Tran, Aaron Broun, Kai Ge DOI: 10.1128/MCB.00341-20 ABSTRACT Lysine demethylase 6A (KDM6A), also known as UTX, belongs to the KDM6 family of histone H3 lysine 27 (H3K27) demethylases, which also includes UTY and KDM6B (JMJD3). The KDM6A protein contains six tetratricopeptide repeat (TPR) domains and an enzymatic Jumonji C (JmjC) domain that catalyzes the removal of di- and trimethylation on H3K27.
Sn4+ and S2- co-doped N-TiO2-x nanoparticles for simultaneously efficient photocatalytic removal of multi-contaminants
Sn4+ and S2- co-doped N-TiO2-x nanoparticles for simultaneously efficient photocatalytic removal of multi-contaminants Jiahui He, Jin Ye, Kai Ge, Jiayu Cao, Congcong Fu, Zhenxing Li, Yue Zhang and Yongfang Yang Abstract Abstract: N-TiO2-x nanoparticles (NPs) were selected as a basic construction unit for its plenty of Ti3+ and O vacancies on its surface. When S2- and Sn4+ are co-doped into the N-TiO2-x lattice, the positions of O2- and Ti4+ can be replaced, respectively.
Transcriptional and Epigenomic Regulation of Adipogenesis
Minireview Ji-Eun Lee, Hannah Schmidt, Binbin Lai, Kai Ge DOI: 10.1128/MCB.00601-18 ABSTRACT Understanding adipogenesis, the process of adipocyte development, may provide new ways to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated actions of lineage-determining transcription factors and epigenomic regulators. Peroxisome proliferator-activated receptor gamma (PPARγ) and C/EBPα are master “adipogenic” transcription factors.
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