Kairavee Thakkar on Muck Rack

Kairavee Thakkar

As seen in: Nature, The Journal of Clinical Investigation
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Articles

BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition

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By Nicholas A. Pease, Peter Gerges, Dianyu Chen, Kairavee Thakkar, Luis Hernandez, Luis Hernández, Swapnil Keshari, Heping Xu, Nathan Salomonis, Jishnu Das, David Rothstein, Harinder Singh, Bala Ramaswami, Steven Gierlack
| Nature Verified
Abstract Germinal center B cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1, are known. We reveal an unsuspected role for BLIMP1 (Prdm1)—a plasma cell determinant—as a feedback regulator of affinity maturation.
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A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice - Nature Immunology

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By Kyle Ferchen, Xuan Zhang, Kairavee Thakkar, Guangyuan Li, Priyanka Rawat, Josh Croteau, Samantha Morris, Harinder Singh, Nathan Salomonis
| Nature Verified
Abstract Large-scale, unbiased single-cell genomics studies of complex developmental compartments, such as hematopoiesis, have inferred novel cell states and trajectories; however, further characterization has been hampered by difficulty isolating cells corresponding to discrete genomic states.
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Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis

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By Emely L. Verweyen, Kairavee Thakkar, Sanjeev Dhakal, Elizabeth Baker
| The Journal of Clinical Investigation
ResearchInflammation Open Access | 10.1172/JCI166741 J Clin Invest. https://doi.org/10.1172/JCI166741. Copyright © 2023, Verweyen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Systemic autoimmune and autoinflammatory diseases are characterized by genetic and cellular heterogeneity.
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