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Articles by Kaiting Yang
Metal–organic framework nanovaccines for systemic tumour regression
Abstract Cancer vaccines can elicit antigen-specific antitumour immunity, but their clinical efficacy is often limited by their inability to sustain T-cell activation in tumours. Here we report MOF-Vac, a nanoscale metal–organic framework (MOF)-based therapeutic vaccine platform that co-delivers peptide antigens and STING agonists with high loading capacity and phosphate-triggered intracellular release.
Membranolytic peptide programs immunogenic cell death for cancer therapy
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Abstract A rational design for facilitating innovative cell death modes can substantially aid advances in antitumour therapy1,2. Here we design and implement a unique mode of immunogenic membranolytic cell death (mLCD) in tumour cells, characterized by time-lagged rupture from the lysosomal to plasma membranes; this approach was found to robustly potentiate immune checkpoint blockade therapy.
By Yueling Yuan, Lifang Liang, Jie Li, Fuxiang Wang, Kai Yan, Jingxian Chen, Fan Lan, Zining Wu, Rupei Du, Yaofeng Zhou, Long Zou, Zhouming Zhang, Yuhao Zhang, Yajing zhang, Penghui Zhou, Tianmeng Sun, Kaiting Yang, Zhibin Zhao, Zhexiong Lian, Shiyan Xiao, Jianjun Cheng, Yan Bao, Menghua Xiong, Chengrun Li, Chanjuan Su, Xiongwei Xiang, Jueqiong Xu, Huosheng Zhou, Songyin Huang
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Nature
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Engineered probiotic Bifidobacterium for tumor-targeted pancreatic cancer therapy
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pancreatic ductal adenocarcinoma (PDAC) presents a substantial challenge due to its resistance to cancer treatments. This limited efficacy is, in part, attributed to the immunosuppressive tumor microenvironment (TME), which impairs effector T (Teff) cell activity.
Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-08994-0 Published online 14 May 2025 In the version of this article initially published, in the last paragraph of the Competing Interests section, “A. Piffkó has consulted for Related Sciences/Danger Bio and owns equity in Danger Bio” should have read “A. Panda has consulted for Related Sciences/Danger Bio and owns equity in Danger Bio”. Additionally, in Fig.
NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature
Abstract Cancer-associated fibroblasts (CAFs) have a pivotal cancer-supportive role, yet CAF-targeted therapies are lacking1,2. Here, using spatial transcriptomics and single-cell RNA sequencing, we investigate the role of nicotinamide N-methyltransferase (NNMT) in high-grade serous ovarian cancer. Mechanistically, NNMT-induced H3K27me3 hypomethylation drives complement secretion from CAFs, attracting immunosuppressive myeloid-derived suppressor cells (MDSCs) to the tumour.
Radiation-induced amphiregulin drives tumour metastasis - Nature
Abstract The anti-tumour effect of radiotherapy beyond the treatment field—the abscopal effect—has garnered much interest1. However, the potentially deleterious effect of radiation in promoting metastasis is less well studied. Here we show that radiotherapy induces the expression of the EGFR ligand amphiregulin in tumour cells, which reprogrammes EGFR-expressing myeloid cells toward an immunosuppressive phenotype and reduces phagocytosis.
Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration - Nature Nanotechnology
Abstract The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a robust tumour-targeted STING agonist, ZnCDA, formed by the encapsulation of bacterial-derived cyclic dimeric adenosine monophosphate (CDA) in nanoscale coordination polymers.
RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy
Translational Science Wenxin Zheng, Diana Rose E. Ranoa, Xiaona Huang, Yuzhu Hou, Kaiting Yang, Elizabeth C. Poli, Michael A. Beckett, Yang-Xin Fu and Ralph R. Weichselbaum DOI: 10.1158/0008-5472.CAN-20-2324 Published December 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Dendritic cells (DC) play an essential role in innate immunity and radiation-elicited immune responses.
RIG-I-like receptor LGP2 is required for tumor control by radiation therapy
Research Article Wenxin Zheng, Diana Rose E. Ranoa, Xiaona Huang, Yuzhu Hou, Kaiting Yang, Elizabeth C. Poli, Michael A. Beckett, Yang-Xin Fu and Ralph R. Weichselbaum DOI: 10.1158/0008-5472.CAN-20-2324 Abstract Dendritic cells (DC) play an essential role in innate immunity and radiation-elicited immune responses. LGP2 is a RIG-I like receptor (RLR) involved in cytoplasmic RNA recognition and anti-viral responses.
Alert: Highlights of Hong Kong SAR Government’s Policies in Light of COVID-19 | JD Supra
Updated: May 25, 2018: JD Supra is a legal publishing service that connects experts and their content with broader audiences of professionals, journalists and associations.
T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response
B cell-derived lymphotoxin (LT) is required for the development of follicular dendritic cell clusters for the formation of primary and secondary lymphoid follicles, but the role of T cell-derived LT in antibody response has not been well demonstrated. We observed that lymphotoxin β-receptor (LTβR) signaling is essential for optimal humoral immune response and protection against an acute herpes simplex virus 1 (HSV-1) infection.
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