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Articles by Kan Chen
Efficacy and safety of GC001: an oncolytic vaccinia virus expressing STRIP1 shRNA
Abstract GC001, a thymidine kinase deleted oncolytic vaccinia virus expressing striatin-interacting protein 1 (STRIP1) shRNA, has been approved by National Medical Products Administration (NMPA) of China to enter phase I clinical trial in 2023. Anti-tumour efficacy of GC001 across multiple cancer types was evaluated in mouse xenograft models. Anti-tumour immune responses were investigated in immunocompetent or humanised cancer mouse model.
Re-enchantment in Adolescent Psyche: Spiritual Experiences in Video Games and Dreams
Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References , & (2013). More than just fun and games: The longitudinal relationships between strategic video games, self-reported problem solving skills, and academic grades. Journal of youth and adolescence, 42(7), 1041-1052. American Psychiatric Association. (2013). Internet gaming disorder.
Quantitative Analysis of the Delay Fiber Length Requirement for Accurate Laser Linewidth Measurement in Self-Heterodyne Method
1 Introduction Lasers are indispensable in fields such as laser processing, optoelectronic sensing, medical diagnostics, and military applications [1-3]. Laser linewidth is a critical performance parameter, as it directly determines processing precision and sensing sensitivity [4, 5]. With the advent of narrow-linewidth lasers reaching the kilohertz (kHz) level [6-8], stringent requirements have been imposed on measurement accuracy.
163 ACETIC ACID-ASSISTED ENDOSCOPIC COLD SNARE POLYPECTOMY FOR COLORECTAL SESSILE SERRATED LESION OF 5~9 MM: A MULTICENTER RANDOMIZED CONTROLLED TRIAL (THE “ACOSER” STUDY)
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Modeling the Regulation Processes of Nutrient Regimes on the Long-Term Diatom-Dinoflagellate Succession in the Bohai Sea
2.3.1.2 Bi-Phytoplankton (bP) Diatoms (PD): biomass (PDB, μg Chl-a/L), particulate N/P/Si (PDN/PDP/PDSi) Dinoflagellates (PF): biomass (PFB, μg Chl-a/), particulate N/P (PFN/PFP) In the model, particulate N/P is derived from phytoplankton biomass using the conversion Equations 3-6 (Text S1 in Supporting Information ), parameterized with the and values provided in Table S4 of Supporting Information .
Design and Monte Carlo-based accuracy analysis: a full-Stokes, division-of-amplitude, thin-film lithium niobate polarimeter
Polarization measurement is critical for photonic applications. With the advancement of low-cost, high-density multifunctional photonic integrated circuits (PICs), polarimeters that can be integrated with other on-chip devices have become increasingly attractive.
Planar-scalable interferometric design enabled by superlattice waveguide arrays
Integrated optical waveguide systems have emerged as foundational components for next-generation sensing technologies, owing to their exceptional miniaturization, high integration density, and compatibility with scalable planar fabrication. However, a persistent architectural bottleneck remains in on-chip interferometric systems, where conventional designs have not yet fully harnessed the potential of the waveguide platform to enhance interference efficiency and detection performance.
Doping and thermoelectric properties of the zero-dimensional inorganic halide perovskite derivative, Cs₃Cu₂I₅
Doping and thermoelectric properties of the zero-dimensional inorganic halide perovskite derivative, Cs₃Cu₂I₅ Halide perovskites have been considered as promising thermoelectric materials due to their unusual combination of good charge mobility and ultralow thermal conductivity.
Innovative vaccine research through the lens of implementation science: fulfilling the strategic goals of the Immunization Agenda 2030 - BMC Global and Public Health
Recognizing the significant contribution of immunization to controlling many common infectious diseases in countries where it has been effectively implemented, the World Health organization (WHO) endorsed the Expanded Programme on Immunization (EPI) in 1974.
Parent‐adolescent emotional communication patterns and adolescent depressive symptoms: A dyadic, mixed methods study
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description jora70010-sup-0001-TableS1-S4.docxWord 2007 document , 35.7 KB Tables S1-S4 REFERENCES (2020). Parent–child relationship satisfaction: The influence of family communication orientations and relational maintenance behaviors. The Family Journal, 28(1), 83–89. https://doi.org/10.1177/1066480719896561 , & (1985). Parent-adolescent communication and the circumplex model.
Multiple Resonators Coupling Effect in Waveguide Loss Measurement Using the Fabry-Perot Method
References 1, , , et al., “Review of Silicon Photonics Technology and Platform Development,” Journal of Lightwave Technology 39 (2021): 4374–4389, https://doi.org/10.1109/JLT.2021.3066203. 2, , , et al., “Advances in Lithium Niobate Photonics: Development Status and Perspectives,” Advanced Photonics 4 (2022): 034003, https://doi.org/10.1117/1.AP.4.3.034003.
Guardian-Driven Influenza Vaccination Intentions for Children Post-COVID-19 in the 2024-2025 season: The Positive Spillover Effects
Letter to the EditorArticles in Press106333Open access 1Institute of Infectious Disease and Vaccine, School of Public Health, Zhejiang Chinese Medical University, No. 548, Binwen Rd, Hangzhou China 310053 2Center for Vaccine Impact Assessment, Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products, National Medical Products Administration, No.548, Benwen Rd, Hangzhou, 310053, China Publication History: Accepted October 22, 2024; Published online October 27,...
Comparison of bilateral ligaments after unilateral anterior cruciate ligament reconstruction: Based on magnetic resonance imaging analysis
Discussion In this study, it was found that the coronal and sagittal plane inclination angles of the knee joint on the operative side were larger than those on the healthy side, with both the medial and lateral tibial plateaus showing forward movement. At the same time, the good consistency of FTA and RTS makes it possible for us to evaluate the static rotation of the knee joint. Previous studies have reported that the inclination angle of autologous ACL varies remarkedly.
Spectrum of the molecular pentaquarks
We investigate the mass spectrum of the molecular pentaquarks composed of a baryon and a meson. We establish the underlying relations among the near-threshold interactions of the molecular tetraquark and pentaquark systems. We find the existence of the molecule candidates in the ΣcD¯(*), DD*, and DD¯* systems indicates a substantial presence of the hadronic molecules in the heavy baryon plus heavy meson systems (heavy refers to the hadrons with the c and/or s quarks).
SU(3) breaking effect in the ${Z}_{c}$ and ${Z}_{cs}$ states
Based on the hadronic resonance picture, we explore a unified framework to describe the observed Zcs and Zc states that are close to the thresholds of the D(*)D¯s(*) and D(*)D¯(*) systems, respectively. We assume that the Zcs(4000) and Zcs(3985) are two different states.
Entering the Next Dimension: A Review of 3D User Interfaces for Virtual Reality
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Hazardous and Toxic Material Decontamination Facility Training in Virtual Reality
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Leveraging Feature Extraction and Context Information for Image Relighting
1. Introduction Example-based image relighting is an important topic in computer vision and graphics. It renders the scene of the input image under new lighting conditions of a given example target image to generate an output. Image relighting has several practical applications and can significantly impact various fields, such as Virtual Reality (VR), Augmented Reality (AR), product visualization, forensics and surveillance, and art restoration and conservation.
Application Research of Mathematica Software in Calculus Teaching
Application Research of Mathematica Software in Calculus Teaching Autores: Lei Xu, Kan Chen Localización: Applied Mathematics and Nonlinear Sciences, ISSN-e 2444-8656, Vol. 8, Nº. 1, 2023, págs. 1785-1792 Idioma: inglés Enlaces Texto completo Under the background of teaching in the new era, image recognition, operation, and processing of experimental data are still the focus of calculus teaching. Mathematica has powerful functions as mathematical software andwas developed by Wolfram Research.
Comparison between the ${P}_{\ensuremath{\psi}}^{N}$ and ${P}_{\ensuremath{\psi}s}^{\mathrm{\ensuremath{\Lambda}}}$ systems
Abstract We construct the effective potentials of the PψN and PψsΛ states based on the SU(3)f symmetry and heavy quark symmetry. Then we perform the coupled-channel analysis of the lowest-isospin PψN and PψsΛ systems. The coupled-channel effects play different roles in the PψN and PψsΛ systems. In the PψN systems, this effect gives minor corrections to the masses of the PψN states. In the PψsΛ system, the ΛcD¯s−ΞcD¯ coupling will shift the mass of the PψsΛ(4338)0 close to the ΞcD¯ threshold.
A Hollow-Core Photonic-Crystal Fiber-Optic Gyroscope Based on a Parallel Double-Ring Resonator
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Light depolarization based on dispersion degree of polarization
Abstract The dispersion degree of polarization, a new definition of the depolarization degree of partially polarized beams, is first proposed, to the best of our knowledge, to measure the performance of fiber depolarizers. First, the description of the polarization based on the Poincaré sphere is introduced. Then, the modified Delaunay triangulation algorithm is introduced, and the calculation formula of the dispersion degree of polarization is given based on this algorithm.
Structural and Electronic Evolution in the Cu3SbS4-Cu3SnS4 Solid Solution
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Crystal Structure and Improved Thermoelectric Performance of Iron Stabilized Cubic Cu3SbS3 Compound
B. Du, R. Zhang, M. Liu, K. Chen, H. Zhang and M. Reece, J. Mater. Chem. C, 2018, Accepted Manuscript , DOI: 10.1039/C8TC05301D If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.
Enhanced thermoelectric performance of Sn-doped Cu3SbS4
Cu SbS is an earth-abundant and low-cost alternative thermoelectric material for medium temperature applications. Tin doping into Cu SbS yields materials with high thermoelectric performance. The electronic structure of Sn-doped Cu SbS was studied using both hybrid density functional theory (DFT) and the quasi-particle self-consistent GW (QSGW) approach.
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
Poor survival rates of patients with tumors arising from or disseminating into the brain are attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (BBB) penetration of chemotherapies/targeted agents, and an intrinsic tumor radio-/chemo-resistance. Ataxia-telangiectasia mutated (ATM) protein orchestrates the cellular DNA damage response (DDR) to cytotoxic DNA double-strand breaks induced by ionizing radiation (IR).
U.S. | The trade deficit: Don’t fear the beast
U.S. | The trade deficit: Don’t fear the beast By Amanda Augustine, Kan Chen, Shushanik Papanyan Public perception towards the trade deficit has shifted from being fact-based to sentiment-based. Economic pattern of the deficit strongly correlates with the structural shift in the U.S. economy. U.S. has a higher per capita deficit with Ireland and Germany than it does with China or Mexico
Screening for Cu-S based thermoelectric materials using crystal structure features
Cu–S based compounds are eco-friendly minerals, and some of them are potential thermoelectric materials for mid temperature range usage. These minerals belong to a large family, in which many compounds have never been investigated as thermoelectric materials.
The Role of Lone-Pair Electrons on the Lattice Thermal Conductivity of Thermoelectric Compound CuSbS2
The discovery and design of compounds with intrinsically low thermal conductivity, especially compounds with special bonding nature and stable crystal structure, is a new direction to broaden the scope of potential thermoelectric (TE) materials. This study revealed unambiguously the origin of the role of the lone pair electrons on lattice thermal conductivity in Cu-Sb-S compounds by correlating the special bonding on Sb site with the phonon dispersion spectrum and density of state.
U.S. Recession Probability Rises to 25%
U.S. has a 25% probability of going into a recession in the next 12 months, based on our estimate. Our model balances factors from financial markets and the manufacturing sector. Deteriorating profits of S&P 500 companies may reflect a weakening global economy
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