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Articles

Eradication of catheter-associated MDR Acinetobacter baumannii biofilms mediated by novel phage encoded depolymerase activity

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By Medhavi Vashisth, Pawan Kumar, Indu Rani, Priya Sharma, Karan Bhutani, Dheeraj Bansal, Nitin Virmani, Rajesh Kumar Vaid, Meenakshi Sharma, Taruna Anand, Prexha Kapoor, Bidhan Chand Bera
| Nature Verified
Abstract Bacteriophage-derived depolymerases provide promising scaffolds for the rational design of next-generation anti-biofilm peptides. We report two novel lytic Caudoviricetes phages φAB440 and φAB441, targeting multidrug-resistant hypermucoviscous Acinetobacter baumannii, encoding tail-associated depolymerases with pectate lyase domains and endolysins featuring glycoside hydrolase motifs.
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