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Medhavi Vashisth on Muck Rack

Medhavi Vashisth

As seen in: Nature
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Articles

Eradication of catheter-associated MDR Acinetobacter baumannii biofilms mediated by novel phage encoded depolymerase activity

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By Medhavi Vashisth, Pawan Kumar, Indu Rani, Priya Sharma, Karan Bhutani, Dheeraj Bansal, Nitin Virmani, Rajesh Kumar Vaid, Meenakshi Sharma, Taruna Anand, Prexha Kapoor, Bidhan Chand Bera
| Nature Verified
Abstract Bacteriophage-derived depolymerases provide promising scaffolds for the rational design of next-generation anti-biofilm peptides. We report two novel lytic Caudoviricetes phages φAB440 and φAB441, targeting multidrug-resistant hypermucoviscous Acinetobacter baumannii, encoding tail-associated depolymerases with pectate lyase domains and endolysins featuring glycoside hydrolase motifs.
Open in Who Shared Issue with article?

Synergy of a virulent phage (φAB182) with antibiotics leading to successful elimination of biofilms formed by MDR Acinetobacter baumannii

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By Medhavi Vashisth, Shikha Yashveer, Anu Bala Jaglan, Nitin Virmani
| cdnsciencepub.com
Abstract Emergence of multiple drug resistant (MDR) strains of Acinetobacter baumannii and a withering drug discovery pipeline necessitates the search for effective alternatives to replace or synergize with currently used antibiotics. In this report, we have described the synergy assessment of a virulent Acinetobacter baumannii phage φAB182 with a wide range of antibiotics. Myophage φAB182 was isolated from sewage against MDR A. baumannii and exhibited maximum stability at 25 °C and pH 7.
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