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Karin Bartel

As seen in: Nature, ScienceDirect, The Journal of Biological Chemistry
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Articles

The structure and assembly of the hetero-octameric BLOC-one-related complex

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By Nelson Arispe, Karin Bartel, Karin von Schwarzenberg, Hopi Lin
| ScienceDirect Verified
Lysosomes are degradative organelles that contain digestive enzymes for the breakdown and recycling of various cellular components, functioning as signaling hubs to coordinate cellular metabolism with intracellular signaling.1,2 In response to intra-/extracellular stimuli, lysosomes can adjust their shape, size, and position to participate in controlling different cellular processes, such as antigen presentation, plasma membrane repair, exosome release, cellular adhesion and migration, and...
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Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis - Nature Communications

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By Carla Abrahamian, Eva-Maria Weiden, Maria S. Soengas, Thomas C. Frohlich Verified, Cheng-Chang Chen, Karin Bartel, Veronika Kudrina, Solveig Kuss
| Nature Verified
Abstract Melanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer. Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low levels of melanin are at particular risk. Humans carrying gain-of-function polymorphisms in the melanosomal/endolysosomal two-pore cation channel TPC2 present with hypopigmentation, blond hair, and albinism.
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Differential regulation of AMP-activated protein kinase in healthy and cancer cells explains why V-ATPase inhibition selectively kills cancer cells

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By Karin Bartel, Ludwig Maximilians, Rolf Müller, Karin von Schwarzenberg
| The Journal of Biological Chemistry Verified
Karin Bartel‡, Rolf Müller§ and Karin von Schwarzenberg‡1 ‡Department of Pharmacy, Pharmaceutical Biology, Ludwig Maximilians University, 81377 Munich, Germany §Helmholtz Center for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, and Department of Pharmacy at Saarland University, Saarland University Campus, 66123 Saarbrücken, Germany ↵1 To whom correspondence should be addressed: Dept. of Pharmacy, Pharmaceutical Biology, LMU Munich, Butenandtstr.
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