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Articles by Karin Wirdefeldt
Genetic variation in antidiabetic drug targets: associations with Parkinson’s disease risk and age at onset
Abstract To investigate whether antidiabetic drugs have a biological basis to be repurposed in PD prevention, we applied a drug target Mendelian randomization framework to assess associations between genetic variation in antidiabetic drug targets and PD risk or age at onset (AAO).
Genome-wide association study of copy number variations in Parkinson’s disease
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Abstract We investigated the role of copy number variations (CNVs) in Parkinson’s disease (PD) using genotyping data from 10,815 patients (2731 early-onset PD, EOPD) and 8901 controls from the COURAGE-PD consortium. CNVs were analyzed using a sliding window genome-wide association and burden approach.
By Zied Landoulsi, Nicole Kuznetsov, Claudia Schulte, Ludovica Montanucci, Costin Leu, Lisa-Marie Niestroj, Emadeldin Hassanin, Cloé Domenighetti, Pierre-Emmanuel Sugier, Peter Lichtner, Jens Krüger, Dena Hernandez, Cornelis Blauwendraat, George D. Mellick, Alexander Zimprich, Walter Pirker, Manuela MX Tan, Ekaterina Rogaeva, Anthony E Lang, Sulev Kõks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugénie Mutez, Kathrin Brockmann, Angela B. Deutschländer, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Andrea Quattrone, Monica Gagliardi, Lena F. Burbulla, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Lukas Pavelka, Pierre Kolber, Bastiaan R Bloem, Andrew Singleton, Dan M. Vitale, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Karin Wirdefeldt, Nancy L Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Carl Clarke, Karen Morrison Verified, Dimitri Krainc, Dennis Lal, Alexis Elbaz, Thomas Gasser, Rejko Kruger, MANU SHARMA, Patrick May, Dheeraj Reddy Bobbili, Milena Radivojkov-Blagojevic, Connor Edsall, Georges M. Hadjigeorgiou, Efthimos Dardiotis, Grazia Annesi, Matt J. Farrer
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Nature
Verified
Microscopic colitis is associated with an increased risk of dementia in a Swedish population
AD Alzheimer's disease ATC Anatomical Therapeutic Chemical BMI body mass index CC collagenous colitis CDR cause of Death Register CI confidence interval ESPRESSO Epidemiology Strengthened by histopathology Reports in Sweden HR hazard ratio IBD inflammatory bowel disease ICD International Classification of Diseases LC lymphocytic colitis MC microscopic colitis NPR National Patient Register OR odds ratio PDR Prescribed Drug Register PPI proton pump inhibitors SSRI selective serotonin reuptake...
NLX‐112 Randomized Phase 2A Trial: Safety, Tolerability, Anti‐Dyskinetic, and Anti‐Parkinsonian Efficacy
1 Introduction In Parkinson's disease (PD), conversion of levodopa to dopamine (DA) by dopaminergic neurons diminishes progressively as DA neurons are lost, so it eventually takes place in non-dopaminergic cells and via ectopic DA release.
Gastrointestinal syndromes in Parkinson’s disease: risk factors or comorbidities?
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Clonal hematopoiesis of indeterminate potential and risk of neurodegenerative diseases
Conflict of interest statement The authors declare no conflicts of interest. Supporting Information Filename Description joim20001-sup-0001-SuppMat.docx2.4 MB Table 1. The 10th version International Classification of Diseases (ICD) Codes for neurodegenerative disease Table 2. Hazard ratios of neurodegenerative diseases among individuals with CHIP with the application of a 3- or 5-years lag time in the follow-up Table 3.
Gastrointestinal syndromes in Parkinson’s disease: risk factors or comorbidities?
Gastrointestinal syndromes in Parkinson’s disease: risk factors or comorbidities? Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register‐based matched cohort study
Summary Background The vagus nerve provides essential parasympathetic innervation to the gastrointestinal system and is known to have anti‐inflammatory properties. Aims To explore the relationship between vagotomy and the risk of inflammatory bowel disease (IBD) and its major categories: Crohn's disease (CD) and ulcerative colitis (UC). Methods A matched cohort comprising 15 637 patients undergoing vagotomy was identified through the Swedish Patient Register from 1964 to 2010.
Family history increases the risk of late seizures after stroke
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