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Dendritic cell redundancy enables priming of anti-tumor CD4 + T cells in pancreatic cancer
Keywords CD4+ T cells cDC2 IFNγ dendritic cells pancreatic cancer PDAC immune checkpoint blockade PD-1 CTLA-4 STING Introduction Pancreatic ductal adenocarcinoma (PDAC) remains one of the most intractable cancers, with a 13% five-year survival rate.1 PDAC cells produce myeloid cell-recruiting chemokines and growth factors, such as CXCL1 and GM-CSF, which establish a highly immunosuppressive tumor microenvironment2,3 and impact systemic metabolism.4 Although CD8+ T cells exist in most human...
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