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Stephanie K Dougan

As seen in: Nature, Science Magazine, Cell Press, Cell Reports, Future Medicine, OncLive, Gastrointestinal Endoscopy
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Articles

Constitutive DUSP2 expression enhances lymphoid cell proliferation by activating CDK1 and promotes lymphomagenesis

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By Yu Qian, Jutatip Panaampon, Bjoern Chapuy, Xueyan Zhang, Xiujuan Zhao, Zhe Wang, Pengfei Zhang, Qiang Ke, Jing Zhong, Ping Yuan, Lei Zhang, Min Hong, Il-Kyu Choi, Jiankun Guan, Dinis Pedro Calado, Scott J. Rodig, Olga Pozdnyakova, Klaus Rajewsky, Susana Godinho, Siwanon Jirawatnotai, Hao Wu, Margaret A. Shipp, Stephanie K Dougan, Baochun Zhang, Tongchai Payungwong, Aretina Zhang
| Cell Reports Verified
Keywords DUSP2, PAC-1 immune cell hematologic malignancies lymphomagenesis cell cycle CDK1 CDC25 Research topic(s) CP: Cancer CP: Immunology Introduction Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases that can dephosphorylate both tyrosine and serine/threonine residues. In humans, the DUSP family comprises 23 members.
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Dendritic cell redundancy enables priming of anti-tumor CD4 + T cells in pancreatic cancer

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By Courtney T.S. Kureshi, Michael Walsh Verified, Rakeeb Kureshi, Victoire Cardot-Ruffino, Dennis A. Agardy, Lestat R Ali, James M. Dougan, Li Qiang, Jiao Shen, Chong Zuo, Patrick Lenehan, S. Wang, Eugena Chang, Joshua Remland, Lauren K. Brais, Thomas E. Clancy, James Cleary, Jason L. Hornick, Brandon Huffman Verified, Joseph D. Mancias, George Molina, Mark Fairweather, Jonathan A Nowak, Kimberly Perez, Douglas A. Rubinson, Sarah Slater, Ritchell van Dams, Jiping Wang, Brian Wolpin, Lei Zhao, Katharine Barrientos, Ruslan D. Novosiadly, Miranda L. Broz, Harshabad Singh, Michael Dougan, Stephanie K Dougan
| Cell Press Verified
Keywords CD4+ T cells cDC2 IFNγ dendritic cells pancreatic cancer PDAC immune checkpoint blockade PD-1 CTLA-4 STING Introduction Pancreatic ductal adenocarcinoma (PDAC) remains one of the most intractable cancers, with a 13% five-year survival rate.1 PDAC cells produce myeloid cell-recruiting chemokines and growth factors, such as CXCL1 and GM-CSF, which establish a highly immunosuppressive tumor microenvironment2,3 and impact systemic metabolism.4 Although CD8+ T cells exist in most human...
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Sa1112 EOSINOPHILIC ESOPHAGITIS AS A COMPLICATION OF IMMUNE CHECKPOINT INHIBITORS

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By Steven Do, Mary Thompson, James M. Dougan, Keri M. Sullivan, Stephanie K Dougan, Michael Dougan, Amiko M Uchida
| Gastrointestinal Endoscopy Verified
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