Katlynn Bugda Gwilt on Muck Rack

Katlynn Bugda Gwilt

As seen in: PNAS, Cell Host & Microbe, Gastrointestinal Endoscopy
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Articles

919 A NOVEL TRUNCATING EP300 MUTATION IMPAIRS INTESTINAL EPITHELIAL DIFFERENTIATION IN PATIENT TISSUE AND ORGANOIDS AND IS RESCUED BY CHEMICAL HDAC INHIBITION

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By Lauren V. Collen, Katlynn Bugda Gwilt, Michael Field, Maiya Whalen, Ashrita Iyengar, Lily Gillette, Geordie Emberling, Kayla Hope, Jeffrey D. Goldsmith, Scott B. Snapper, Jay R. Thiagarajah
| Gastrointestinal Endoscopy
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TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase

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By Katlynn Bugda Gwilt, Dhanushan Wijayratne, Geordie Emberling, Lily Gillette
| biorxiv.org
Abstract The formation of a single central lumen is a critical step for glandular morphogenesis. Patients with loss of function variants in the chaperone protein TTC7A have multiple lumen formation in colonic crypt glands. We show that trafficking and localization of TTC7A to the plasma membrane is required for directionally specifying the apical membrane with TTC7A patient loss-of-function variants leading to mislocalized membrane and lumen formation.
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Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling

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By Aaron T. Whiteley, Wayne I. Lencer, Denis Chang, Katlynn Bugda Gwilt
| PNAS
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling Denis Chang, Aaron T. Whiteley, Katlynn Bugda Gwilt, Wayne I. Lencer, John J. Mekalanos, Jay R. Thiagarajah Proceedings of the National Academy of Sciences Oct 2020, 202015919; DOI: 10.1073/pnas.2015919117
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