Acknowledgments This work was supported as part of the national plan for rare diseases by the Directorate of Health Care Supply of the French Ministry of Health (DGOS). We thank Ann Marshak Rothstein (University of Massachusetts School of Medicine), R. Elsner, J. Tilstra, and R. Gordon for helpful discussions. We thank L.Conter, K. Minjung, M. Price, and T. Marinov for technical support. We thank L. Altman for his help to cross the Tlr779/779 MRL/lpr mice to the 9–/– background, and A.