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Kazuhiro Kobayashi on Muck Rack

Kazuhiro Kobayashi

As seen in: Nature, MDPI, The Japan Times, Science Magazine, Cell Press, Lexology, The Journal of Biological Chemistry
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Articles

Structural insights into spectral tuning and retinal exchange in cone visual pigments

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By Grace A. Pan, Seok-Jin Kim, Kota Katayama, Xuchun Yang, Masahiro Fukuda, Filippo Sacchetta, Ryoji Suno, Yukihiko Sugita, Kazuhiro Kobayashi, Hiroo Imai, So Iwata, Eriko Nango, Takuya Kobayashi, Takeshi Noda, Massimo Olivucci, Hideaki E. Kato, Hideki Kandori, K.P. Lamers, Sayaka Ohashi, Asato Kojima, Nipawan Nuemket, Suhyang Kim
| Science Magazine Verified
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Human daytime vision relies on a trio of visual receptors called opsins, which are found in the cone cells in and around the central region of the retina.
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Structural basis and physiological significance of non-canonical G s coupling to the melatonin MT 1 receptor

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By Atsuro Oishi, Hiroyuki Okamoto, Keisuke Ikegami, Bernard Masri, Tsukasa Kusakizako, Kazuhiro Kobayashi, Angeliki Karamitri, Erika Cecon, Julie Dam, Irina G. Tikhonova, Osamu Nureki, Ralf Jockers, Ronan McHugh, Akifumi Takaki, Miki Nagase
| Nature Verified
Abstract G protein-coupled receptors (GPCRs) transduce extracellular stimuli into intracellular signals by coupling to various heterotrimeric G proteins. However, the rules governing G protein preference remain largely elusive. MT1 and MT2 are prototypical Gi/o-coupled GPCRs responding to melatonin, a hormone secreted in a circadian manner.
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The dynamic basis of G-protein recognition and activation by a GPCR

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By Kazuhiro Kobayashi, Kouki Kawakami, Toshiki E. Matsui, Shun Yokoi, Masahiro Fukuda, Tomohiro Narita, Hiroki Arai, Mai Tambo, Takashi Sumikama, Manae Tatsumi, Keitaro Yamashita, Junki Koyanagi, Mai Kugawa, Hisako Ikeda, Ayumi Sumino, Ayori Mitsutake, Brian K. Kobilka, Asuka Inoue, Hideaki E. Kato
| Nature Verified
Abstract G-protein-coupled receptor (GPCR) signalling occurs through heterotrimeric G proteins, whose selective activation leads to distinct cellular outcomes1. Although more than 200 GPCR–G protein complex structures have been determined2, these static snapshots provide limited insight into the dynamics of G-protein association and dissociation.
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