Ke Zen
China
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Articles by Ke Zen
Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling
Abstract Maternal obesity is linked to heightened metabolic disease risk in offspring, but the mediators of this intergenerational effect remain unclear. Using a diet-induced obesity (DIO) mouse model, we showed that maternal circulating small extracellular vesicles (sEVs) crossed the placenta and delivered obesity-associated miRNAs to the fetal liver, with lasting consequences for insulin sensitivity in male offspring.
Migrasomes mediate viral infection across various cell types
Dear Editor, We read with great interest the recent work by Lu Lv and Leiliang Zhang suggesting the potential role of migrasomes in spreading of poxvirus1. Utilizing various viruses as well as their host cells, here we demonstrate that migrasomes released by infected cells contain intact virus particles, and more importantly, migrasomes mediate the spreading of virus to the cells without expression of the specific viral receptor.
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis
Keywords cuproptosis hypoxia hypoxia inducible factor-1α lipoylation solid tumors Introduction Copper plays a crucial role as a fundamental metallic element within the human body, acting as a cofactor for enzymes involved in critical functions such as mitochondrial respiration, oxidation-reduction reactions, and biomolecule synthesis.1,2 While earlier investigations have shown that copper can induce cell death, the precise mechanisms behind copper-triggered cell demise remain controversial.3...
siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection
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Keywords exosome small RNA RNA delivery gene silencing antibiotic resistance MRSA in vivo self-assembled siRNA translational repression AGO Introduction Multidrug-resistant bacteria pose a major threat to human health.1,2 As the introduction of new drugs is significantly slower than the spread of antibiotic resistance, new therapeutic strategies for drug-resistant bacteria are urgently needed.
By Chen Wang, Wangjian Sheng, Yu Zhou, Xudong Hang, Jiayi Zhao, Yuanyuan Gu, Xiangfeng Meng, Yuefan Bai, Weili Li, Yujing Zhang, LinLin Zhang, Jing Yu, Zhen Zhou, Xiaona Li, Haorui Sun, Yanhong Xue, TAO XU Verified, Ke Zen, Chen-Yu Zhang, Hongkai Bi, Huan Wang
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Cell Reports Medicine
Verified
Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice - Nature Communications
Abstract During cold exposure, activated brown adipose tissue (BAT) takes up a large amount of circulating glucose to fuel non-shivering thermogenesis and defend against hypothermia. However, little is known about the endocrine function of BAT controlling glucose homoeostasis under this thermoregulatory challenge. Here, we show that in male mice, activated BAT-derived extracellular vesicles (BDEVs) reprogram systemic glucose metabolism by promoting hepatic gluconeogenesis during cold stress.
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy
Abstract Radiotherapy (RT)-induced tumoricidal immunity is severely limited when tumors are well-established. Here, we report that depleting SIRPα on intratumoral macrophages augments efficacy of RT to eliminate otherwise large, treatment-resistant colorectal (MC38) and pancreatic (Pan02 and KPC) tumors, inducing complete abscopal remission and long-lasting humoral and cellular immunity that prevent recurrence.
Receptor for Advanced Glycation Endproducts Mediates Neutrophil Migration across Intestinal Epithelium
Abstract Receptor for advanced glycation endproducts (RAGE) is an Ig superfamily cell surface receptor that interacts with a diverse array of ligands associated with inflammatory responses. In this study, we provide evidence demonstrating that RAGE is involved in inflammatory responses in the intestines. We showed that RAGE is expressed in intestinal epithelial cells, primarily concentrated at the lateral membranes close to the apical cell junction complexes.
Controlling macrophage phagocytosis towards healthy self cells: Two layers of activating and inhibitory mechanisms
Rapid clearance of adoptively transferred CD47-null cells in mice suggests a critical self-recognition mechanism, in which CD47 is the ubiquitous marker of ‘self’, and its interaction with macrophage SIRPα triggers inhibitory signaling through SIRPα cytoplasmic ITIMs and tyrosine phosphatase SHP-1/2.
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