Yingyi Qiu

Keywords cuproptosis hypoxia hypoxia inducible factor-1α lipoylation solid tumors Introduction Copper plays a crucial role as a fundamental metallic element within the human body, acting as a cofactor for enzymes involved in critical functions such as mitochondrial respiration, oxidation-reduction reactions, and biomolecule synthesis.1,2 While earlier investigations have shown that copper can induce cell death, the precise mechanisms behind copper-triggered cell demise remain controversial.3...