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Kelley Faber

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CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET - Nature Communications

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By Shannon L. Risacher, Paula J Bice, Jared Brosch, Kelley Faber, Martin R Farlow, Tatiana Foroud, Thea J. Rosewood, Jun kim, Kelly Nudelman, Meichen Yu, Reisa Sperling, William Jagust, Aparna Vasanthakumar, Vincent Doré, Simon Laws, Tenielle Porter, Christopher Rowe, Timothy J. Hohman, Rachel Buckley, Hyun-Sik Yang, Ronald Petersen, Vijay Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, M. Ilyas Kamboh, Oscar Lopez Verified, Muhammad Shoaib Ali, Carlos Cruchaga, Diana A. Hobbs, Vaishnavi Jadhav, Bruce Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Lifestyle study
| Nature Verified
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron emission tomography in 3046 participants from 12 independent studies. The CYP1B1-RMDN2 locus is associated with tau deposition.
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