Kelvin Lau on Muck Rack

Kelvin Lau

Geneva, Lausanne, Toronto, Vancouver
As seen in: Nature, Wiley Online Library, MDPI, Cell Press, The Lancet, AllEvents, medRxiv, The Journal of Biological Chemistry, Journal of Infection, Lung Cancer and
🇨🇦🇭🇰 @EPFL_en protein production + structure facility 🇨🇭| ex @ubc @uwaterloo @unige_en | #proteins #plants #transit #cats #politics | My views + ☁️ 🪡 🐘
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Articles

Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme

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By Sandro Fischer, Anton Natter Perdiguero, Kelvin Lau, Alexandria Deliz Liang
| Nature Verified
Abstract Hydrophobicity controls many aspects of protein and enzyme function. Although hydrophobic tuning can be somewhat achieved with canonical amino acids, the incorporation of non-canonical amino acids further extends this ability to enable new and improved functionality. Here we engineer an aminoacyl-tRNA synthetase/tRNA pair for the site-specific genetic encoding of a set of bulky, hydrophobic amino acids, namely cyclopentylalanine, cyclohexylalanine and cycloheptylalanine.
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Construction of dual-cofactor artificial metalloenzymes for synergistic and enantiodivergent catalysis of Michael addition reactions - Nature Synthesis

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By Weijin Wang, Xinjian Ji, Kelvin Lau, Thomas Ward, Pol Gorrea-Acín
| Nature Verified
Abstract Artificial metalloenzymes (ArMs) offer a promising tool for catalytic organic synthesis with abiotic activities. Although synergistic catalysis has been widely applied in small-molecule systems, it has rarely been implemented in ArMs, in part owing to the challenge of assembling synergistic cofactors within a protein scaffold.
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Personalized Synergy-based Functional Electrical Stimulation Improves Lower Limb Motor Functions of Chronic Stroke Survivors by Restoring Gait Control Modules

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By Xiaoyu Guo, Kelvin Lau, Minglei Bai, Richard Liu
| medRxiv
The authors have declared no competing interest. NCT04155866/NCT04154514 This study was funded by the Research Grants Council of the Hong Kong Special Administrative Region, China (Project Nos. R4022-18, N_CUHK456/21, 14114721, 14119022, and STG1 M-401_24-N to V.C.K.C.), grants from The Chinese University of Hong Kong (Project Nos. 2020095, 2021.065 for Faculty of Medicine, and project "Impact Case C7" for Research Committee, to V.C.K.C.).
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