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Ken Xie on Muck Rack

Ken Xie

As seen in: Forbes, Nature, Agenda (World Economic Forum), VentureBeat, Cell Press, Investor's Business Daily, CSO, Network World, Gulf Business, CyberScoop and
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Articles

EasySCP unveils extensive liver zonation at single-cell proteomics resolution

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By Bingbing Hao, Jinghui Wei, Jiaen Xu, Ying Fu, Xu Wang, Siyu Wang, Yixuan Shi, Yale Tung Chen, Ken Xie, Xun Huang, Tong-Jin Zhao, Zigang Dong, Peng Li, Guochen Qin, Ido Amit, Baoguo Li, Qiaoyu Zou
| Nature Verified
Abstract The broader application of single-cell proteomics (SCP) in biology has been limited by complex workflows and reliance on specialized instrumentation. Here we present EasySCP, a high-throughput method that integrates FACS-based single-cell sorting, an all-in-one, single-step digestion process in 384-well plates, and sensitive mass spectrometry. EasySCP identifies nearly 5000 proteins from individual HEK293 cell.
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Tumor-antigen-independent targeting of solid tumors by armored macrophage-directed anti-TREM2 CAR T cells

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By Gal Yagel, Michelle von Locquenghien, Roberto Avellino, Paulina Chalan, Ken Xie, Fadi Sheban, Kfir Mazuz, Eyal David, Pascale Zwicky, Ido Amit, Dana Rimini, Oren Barboy, Gaya Granot, Shir Shlomi-Loubaton
| Cell Press Verified
Keywords solid tumor CAR-T armored CAR-T macrophages tumor-associated macrophages cytokines TREM2 IL-12 immunotherapy single-cell sequencing Get full text access Log in, subscribe or purchase for full access. References 1. Sterner, R.C. ∙ Sterner, R.M. CAR-T cell therapy: current limitations and potential strategies Blood Cancer J. 2021; 11, 69 2. Marofi, F. ∙ Motavalli, R. ∙ Safonov, V.A. ... CAR T cells in solid tumors: challenges and opportunities Stem Cell Res. Ther. 2021; 12:81 3.
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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By Michelle von Locquenghien, Pascale Zwicky, Ken Xie, Diego Adhemar Jaitin, Fadi Sheban, Adam Yalin, Florian Uhlitz, Chamutal Gur, Eyal David, Kfir Mazuz, Caroline Jennings Marin, Ankita Sankar, Devin Mediratta, Roberto Avellino, Assaf Weiner, Ido Amit
| Cell Press Verified
Keywords cancer immunotherapy myeloid checkpoints tumor-associated macrophages cytokines tumor-microenvironment modulation TREM2 TME-conditional IL-2 myeloid-targeted immunocytokine T and NK cell synergy single-cell genomics synthetic immunology Get full text access Log in, subscribe or purchase for full access. References 1. Sharma, P. ∙ Hu-Lieskovan, S. ∙ Wargo, J.A. ... Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy Cell. 2017; 168:707-723 2.
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