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Kenyon Weis

As seen in: Nature, Cell Press
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Articles

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53 -mutant clonal hematopoiesis

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By Pu Zhang, Xiangyu Pan, Cynthia Castro, Nina Fox, Alexander Lewis Verified, Kenyon Weis, Adriana M. Cuibus, Steven Tittley, J. Scott Beeler, Duc Thanh Tran, Catrina C Fronick, Konrad H. Stopsack, Carlos Cruchaga, Omar Abdel-Wahab Verified, Kelly Bolton, Irenaeus C. C. Chan, Giulia Petrone, Griffen Mustion
| Nature Verified
Abstract Therapy-related myeloid neoplasm (tMN) is a fatal consequence of exposure to cytotoxic therapy administered in the treatment of cancer. Individuals with pre-existing TP53 clonal hematopoiesis (CH) are at high risk of tMN, with avoidance of therapy being the only strategy to reduce tMN risk.
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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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By Eli L. Diamond, Jean-François Emile, Takeshi Fujino, Julien Haroche, Maxim I. Maron, Alexander Lewis Verified, Jahan A. Rahman, Anne Reiner, Dana F. Bossert, Marc K. Rosenblum, Mariko Yabe, Kseniya Petrova-Drus, Jasmine H. Francis, Veronica Rotemberg, Raajit Rampal, Sarah Paiji Yoo, Anthony F. Daniyan, sonia mahajan, Vaios Hatzoglou, Robert Young, Gary A. Ulaner, Wiebke Rösler, Oshrat Hershkovitz-Rokah, Ofer Shpilberg, Roei D. Mazor, Michael Singer Verified, M. Adriana Cuibus, Salima Benbarche, Pu Zhang, Nina Fox, Cynthia Castro, Matthew Witkowski, Fleur Cohen-Aubart, Louis Terriou, Maher Hanoun, Nicolas Schleinitz, Gabriela Sosa, Timo Hautala, Neal Rosen, Omar Abdel-Wahab Verified, Benjamin H. Durham, Kenyon Weis, Steven Tittley
| Cell Press Verified
Keywords BRAF cobimetinib Erdheim-Chester disease histiocytoses Langerhans cell histiocytosis macrophage MEK ERK trametinib ulixertinib Introduction Histiocytic neoplasms (histiocytoses) are a diverse group of clonal hematopoietic disorders defined by the accumulation of macrophages, dendritic cells, or monocyte-derived cells in various tissues.1 Histiocytoses subtypes include Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), juvenile xanthogranuloma (JXG),...
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