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Fleur Cohen-Aubart

As seen in: Annals of the Rheumatic Diseases, JAMA (The Journal of the American Medical Association), Cell Press, EClinicalMedicine, The Lancet
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Articles

RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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By Eli L. Diamond, Jean-François Emile, Takeshi Fujino, Julien Haroche, Maxim I. Maron, Alexander Lewis Verified, Jahan A. Rahman, Anne Reiner, Dana F. Bossert, Marc K. Rosenblum, Mariko Yabe, Kseniya Petrova-Drus, Jasmine H. Francis, Veronica Rotemberg, Raajit Rampal, Sarah Paiji Yoo, Anthony F. Daniyan, sonia mahajan, Vaios Hatzoglou, Robert Young, Gary A. Ulaner, Wiebke Rösler, Oshrat Hershkovitz-Rokah, Ofer Shpilberg, Roei D. Mazor, Michael Singer Verified, M. Adriana Cuibus, Salima Benbarche, Pu Zhang, Nina Fox, Cynthia Castro, Matthew Witkowski, Fleur Cohen-Aubart, Louis Terriou, Maher Hanoun, Nicolas Schleinitz, Gabriela Sosa, Timo Hautala, Neal Rosen, Omar Abdel-Wahab Verified, Benjamin H. Durham, Kenyon Weis, Steven Tittley
| Cell Press Verified
Keywords BRAF cobimetinib Erdheim-Chester disease histiocytoses Langerhans cell histiocytosis macrophage MEK ERK trametinib ulixertinib Introduction Histiocytic neoplasms (histiocytoses) are a diverse group of clonal hematopoietic disorders defined by the accumulation of macrophages, dendritic cells, or monocyte-derived cells in various tissues.1 Histiocytoses subtypes include Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), juvenile xanthogranuloma (JXG),...
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Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration

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By Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Meyer, Yang Hu, Masato Ogishi, Araitz Alberdi, Oyku Ay, Isabelle Plu, Sébastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Estibaliz Lopez-Rodrigo, Ann Baako, Véronique Sazdovitch, Makoto Mi
| Cell Press Verified
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Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration

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By Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Meyer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Véronique Sazdovitch, Sébastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Makoto Miyara, Florence Nguyen-Khac, Agnes Viale, Ahmed Idbaih, Zahir Amoura, Marc K. Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub, Palash Sashittal, Akhil Jakatdar, Christine A. Iacobuzio-Donahue, Omar Abdel-Wahab Verified, Viviane Tabar, Nicholas D. Socci, Olivier Elemento, Eli L. Diamond, Bertrand Boisson, Jean-Laurent Casanova Verified, Danielle Seilhean, Julien Haroche, Jean Donadieu, Frederic Geissmann
| Cell Press Verified
Keywords Neurodegeneration MAPK pathway microglia hippocampus brainstem resident macrophages Introduction Langerhans cell histiocytosis (LCH)1 and Erdheim-Chester disease (ECD)2,3 are rare clonal myeloid disorders, with an estimated incidence of ∼5 cases per million people per year.4 They are sometimes co-diagnosed in the same patients,5 and both associated with a high prevalence of the BRAFV600E mutation1,2,3,6,7,8 as well as an increased risk of neurodegenerative disease...
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