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Keon Wook Kang

As seen in: Nature, MDPI
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Articles

Prenatal valproic acid exposure alters striatal proteomic signatures associated with autism spectrum disorder in mice

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By Yunjung Choi, Han-Byeol Kim, Ran-Sook Woo, Dohyun Han, Mina Kang, Yoori Choi, Keon Wook Kang, Hye-Sun Kim, Eun Hwa Jo, Won-Cheol Kim, Seong June Park
| Nature Verified
Abstract Prenatal exposure to valproic acid (VPA), a widely prescribed antiepileptic and mood‑stabilizing drug, is a well-established environmental risk factor for autism spectrum disorder (ASD). Although behavioral and anatomical abnormalities have been reported in VPA-exposed animal models, the underlying molecular mechanisms within specific brain regions remain unclear.
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ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease

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By Jeongwoo Park, TaeEung Kim, Sung Eun Hong, Miso Park, Bo Kyung Koo, Dong Hyeon Lee, Sae Kyung Joo, Taekyeong Yoo, Young Lee, Sung-Chul Lim, Seung-Yong Seo, Kyu Min Kim, Natalia Cambronero Nieto, Murim Choi, Won Sam Kim, Keon Wook Kang, Seungseok Oh
| Nature Verified
Abstract A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) has been implicated in arthritis and lung fibroblast activation; however, its role in liver homeostasis and fibrogenesis remains largely unexplored. Here, we investigated the functional significance of ADAMTS4 in liver fibrosis. We found that hepatic ADAMTS4 mRNA expression was significantly elevated in patients with fibrotic steatohepatitis.
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Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism - Experimental & Molecular Medicine

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By Sang-Min Jeon, Keon Wook Kang
| Nature Verified
Abstract Histone acetylation involves the transfer of two-carbon units to the nucleus that are embedded in low-concentration metabolites. We found that lactate, a high-concentration metabolic byproduct, can be a major carbon source for histone acetylation through oxidation-dependent metabolism. Both in cells and in purified nuclei, 13C3-lactate carbons are incorporated into histone H4 (maximum incorporation: ~60%).
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