Kevin Corbett on Muck Rack

Kevin Corbett

  • Partner, Deloitte Financial Advisory Services, Deloitte
As seen in: Deloitte, Color Research & Application, Nature, PNAS, Taylor & Francis Online, Science Magazine, Cell Press, ADVFN, BiggerPockets, JD Supra, Annual Reviews Journal and
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Articles

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites

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By Marco Mendoza Aviña, Kenneth Madsen, Dongbin Shin, Midori Ohta, Orie Arakawa, Yajie Gu, Wanying Tian, Kevin Corbett, Arshad Desai, Karen Oegema
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mitotic centrosomes consist of centrioles surrounded by a proteinaceous matrix that docks and activates γ-tubulin complexes (γTuCs) to nucleate microtubules for spindle assembly.
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A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation

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By Valdemar Priebe, Peter Sheridan Dodds, Mohammad A Saad, Johnathan L. Meaders, Alyssa Rodriguez, Smriti Variyar, Sungwoo Park, Alessandro E. Cirulli, Karen Oegema, Kevin Corbett, Arshad Desai
| Science Magazine Verified
Abstract Accurate chromosome segregation requires dynamic kinetochore-microtubule attachments that, under the regulation of Aurora family kinases, biorient and align replicated chromosomes. In Caenorhabditis elegans, Aurora A acts with the TPX2-related activator TPXL-1 to regulate these attachments and control spindle length. We show that, in addition to prominent spindle pole localization, TPXL-1–AurA has a chromatin-associated pool positioned between the sister kinetochores.
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Mechanism and reconstitution of circadian transcription in cyanobacteria - Nature Structural & Molecular Biology

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By Mingxu Fang, Mariusz Matyszewski, Andy LiWang, Yulia Yuzenkova, Kevin Corbett
| Nature Verified
Abstract Circadian biological clocks evolved across kingdoms of life as an adaptation to predictable cycles of sunrise and sunset. In the cyanobacterium Synechococcus elongatus, a protein-based clock precisely controls when different genes are turned on and off during the 24-h day but the phasing mechanism remains unclear. Here we show the molecular basis of this regulation and reconstitute clock-controlled transcription in vitro using purified components.
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