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Kevt’her Hoxha

As seen in: Nature
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Articles

Repositioning of polyubiquitin alters the pathologic tau filament structure

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By Ryohei Watanabe, Benjamin C Creekmore, Nabil F. Darwich, Courtney Smith, Hong Xu, Angelina Baltazar, Lakshmi Changolkar, Kevt’her Hoxha, Bin Zhang, George M. Burslem, Virginia Lee, Yi-Wei Chang, Edward Lee Verified, Sacha Salphati, Caroline M. O’Rourke, Edward Lee
| Nature Verified
Abstract Structurally diverse tau filaments form proteinaceous aggregates in a heterogeneous group of neurodegenerative diseases called tauopathies. The factors extrinsic to the highly ordered core structure that influence tau filament stability are not well understood.
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Intestinal interoceptive dysfunction drives age-associated cognitive decline

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By Timothy Cox, Ashwarya S. Devason, Alan de Araujo, Sydney Mason, Madhav Subramanian, Andrea Salvador Verified, Hélène Descamps, Junwon Kim, Yixuan Zhu, Lev Litichevskiy, Sunhee Jung, Won-Suk Song, Adrián Cortés-Martín, Nathan Henderson, Kuei-Pin Huang, Thao Nguyen Verified, Thảo Nguyen, Wisath Sae-Lee, Iboro C. Umana, Maria A. Sacta, Ryan Rahman Verified, Stephen Wisser, J. Andrew D. Nelson, Ilona Golynker, Alana M. McSween, Eric F. Hohmann, Shaan Patel, Anna L. Bub, Clara Soekler, Niklas Blank, Kevt’her Hoxha, Lavinia Boccia, Andrea Wong, Klaas Bahnsen, Jihee Kim, Natalie Biderman, Dina Abbasian, Clarissa Shoffler, Christopher Petucci, Fiona McAllister, Amber L. Alhadeff, Marc V. Fuccillo, Colin Hill, Cholsoon Jang, J. Nicholas Betley, Guillaume de Lartigue, Virginia Lee, Maayan Levy, Christoph A. Thaiss
| Nature Verified
Abstract Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population1. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions2,3,4,5,6, but the underlying mechanisms remain largely unclear.
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