Khaled Ezzedine
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Nature,
Wiley Online Library,
American Journal of Clinical Dermatology,
JAMA (The Journal of the American Medical Association),
EClinicalMedicine,
Pediatrics,
Dialnet - Universidad de La Rioja,
The Journal of Clinical Investigation,
Journal of The American Academy of Dermatology (JAAD),
EMJ- European Medical Journal
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Articles by Khaled Ezzedine
The Safety of Melasma Treatment in Vitiligo Patients: An International E-Delphi Study
Conflicts of Interest Dr. Abdallah declares no conflicts of interest for this work but has received honoraria, consultancies to sponsoring organizations, paid expert testimony from: Isispharma, Beiersdorf, Bayer, Janssen, Abbvie, Pfizer.
Timing of food intake, chrononutritional behavior patterns, and risk of metabolic syndrome in the French NutriNet-Santé cohort
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Abstract Growing evidence from preclinical studies suggests that meal timing influences metabolic health. However, evidence in humans is inconclusive. This study aims to evaluate the associations between timing and frequency of food intake, energy distribution and chrononutritional behavior patterns, with metabolic syndrome (MetS) risk in a large cohort.
By Anna Palomar-Cros, Sandrine Péneau, Alice Bellicha, Mélanie Deschasaux-Tanguy, Benjamin Allès, Chantal Julia, Emmanuelle Kesse-Guyot, Serge Hercberg, Jean-Michel Oppert, Alexandra Montagner, Hervé Guillou, Mathilde Touvier, Valentina A Andreeva, Khaled Ezzedine, Bernard Srour, Elena Obeid, Xuân Le Folcalvez, Paola Yvroud-Hoyos
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Nature
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Journal of the European Academy of Dermatology and Venereology | Wiley Online Library
Vitiligo remains one of the most challenging autoimmune skin disorders to manage. This is not only because its unpredictable clinical course hinders treatment goals (halting disease progression, inducing repigmentation and sustaining repigmentation), but also due to its profound psychosocial burden.1 To address these complexities, Speeckaert et al.
Journal of the European Academy of Dermatology and Venereology | Wiley Online Library
In this issue of the JEADV, an article by Butt et al.1 studied the psychometric properties of the revised internalized skin bias questionnaire. As the scientific literature accumulates evidence on the mental burden of skin diseases and the influence of psychological stress on their development, it has prompted a need for dermatological research to increasingly—and inevitably—consider complex psychosocial factors in order to further understand the hidden impact of these visible diseases.
Atopic dermatitis in the French cohort CONSTANCES (PreDDA study): Focus on persistence and remission in adulthood
Atopic dermatitis (AD) prevalence has been increasing over the past 20 years, affecting infants but also occurring or persisting into adulthood.1 The main objective of the PreDDA study was to estimate adult prevalence of AD in a French representative population-based cohort of adults (CONSTANCES),2 and to describe factors associated with different profiles of AD.
Recent clinical and mechanistic insights into vitiligo offer new treatment options for cell-specific autoimmunity
Abstract Vitiligo is an autoimmune disease that has been recognized, stigmatized, and treated for millennia. Recent translational research has revealed key mechanisms of disease, including cellular stress, innate immune activation, T cell–mediated elimination of melanocytes from the skin resulting in clinically apparent white spots, as well as stem cell regeneration that reverses established lesions.
Vitiligo, Beyond White Patches
INTRODUCTION Vitiligo is a chronic autoimmune disease caused by a deregulation of the immune response that results in epidermal melanocyte destruction.1 With a variable and unpredictable disease course consisting of stable periods, spontaneous re-pigmentation, and new patches or flares, it should no longer be considered a cosmetic disease.
Psychometric Properties and Meaningful Change Thresholds of the Vitiligo Area Scoring Index
Key Points Question Do the Total Vitiligo Area Scoring Index (T-VASI) and the Facial VASI (F-VASI) demonstrate concept validity and adequate performance in patients with nonsegmental vitiligo?
Once-daily upadacitinib versus placebo in adults with extensive non-segmental vitiligo: a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-ranging study
Summary Janus kinase (JAK) inhibition is a promising approach for treating vitiligo. We aimed to assess the efficacy and safety of upadacitinib, an oral selective JAK inhibitor, in adults with non-segmental vitiligo. This was a phase 2, multicentre, randomised, double-blind, placebo-controlled, dose-ranging study completed at 33 clinical centres in the United States, Canada, France, and Japan.
Vitiligo Patient Population and Disease Burden in France: VIOLIN Study Results From the CONSTANCES Cohort
Background Vitiligo is a chronic autoimmune disease resulting in skin depigmentation. Objectives This study assessed the prevalence, disease burden, and treatment of vitiligo in France. Methods VIOLIN was a cross-sectional study nested in the national CONSTANCES cohort, which consists of randomly selected adults aged 18–69 years in France.
Assessing the Trends of Outcome Measures and Quality of Life Instruments in Vitiligo: A Systematic Review
Khaled Ezzedine Epidemiology in Dermatology and Evaluation of Therapeutics, EA7379, Paris-Est University, Paris Est Créteil University, Département Infectieux/Immuno/Vaccin, Créteil, France Department of Dermatology, Mondor Hospital (Assistance Publique, Hôpitaux de Paris), Paris Est Créteil University, Créteil, France Search for more papers by this author
Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo: A randomized phase 2b clinical trial
Background Vitiligo is a chronic autoimmune disorder characterized by depigmented patches of the skin. Objective To evaluate the efficacy and safety of ritlecitinib, an oral JAK3 (Janus kinase)/TEC (tyrosine kinase expressed in hepatocelluar carcinoma) inhibitor, in patients with active nonsegmental vitiligo in a phase 2b trial (NCT03715829).
Mental Health and Psychosocial Quality-of-Life Burden Among Patients With VitiligoFindings From the Global VALIANT Study
Mental Health and Psychosocial Quality-of-Life Burden Among Patients With VitiligoFindings From the Global VALIANT Study Autores: Kristen Bibeau, Khaled Ezzedine, John E. Harris, Nanja van Geel, Pearl E. Grimes, Davinder Parsad, Mukta Tulpule, Jackie Gardner, Yan Valle, Gaone Tlhong Matewa, Christine LaFiura, Anouk Lindley, Haobo Ren, Iltefat Hamzavi Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 159, Nº. 10, 2023, págs.
Perceived clinical severity of atopic dermatitis in adolescents: Comparison between patients' and parents' evaluation
To the Editor: In atopic dermatitis (AD), a significant discordance between physician-rated and patient-rated clinical severity has often been observed, probably because patients also include other nonclinical aspects in their evaluation. Although patient-physician agreement has been investigated, patient-caregiver agreement has been rarely studied, and caregivers are burdened with treatment issues and psychosocial consequences of the condition. 2 Carroll C.L. Balkrishnan R.
New discoveries in the pathogenesis and classification of vitiligo
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig 1 Vitiligo koebernizing within thyroidectomy scar. Fig 2 Lip-tip variant of vitiligo in a young African girl. Fig 3 Universal vitiligo in an Asian man. Fig 4 Segmental variant of vitiligo on the abdomen of an adolescent boy. Fig 5 Segmental variant of vitiligo on the face and neck of young boy. Fig 6 Trichrome pattern on the neck and shoulders.
Interventions for Vitiligo
Clinical Question Which interventions are associated with highest efficacy and fewest adverse events for treating vitiligo? Bottom Line Combination therapies, particularly those involving some form of light (ie, narrowband UV-B) were associated with more improved repigmentation than monotherapies. There was limited evidence to support the association of UV-A alone and UV-B alone with repigmentation for vitiligo.
A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children
A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children Khaled Ezzedine, Nanette Silverberg Pediatrics Jul 2016, 138 (1) e20154126; DOI: 10.1542/peds.2015-4126
A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children
A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children Khaled Ezzedine, Nanette Silverberg Pediatrics Jun 2016, e20154126; DOI: 10.1542/peds.2015-4126
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