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kimberly nelson’s Journalist Portfolio

Hass and Associates Cyber Security Hvorfor Google ikke vokser

Hass and Associates Cyber Security Hvorfor Google ikke vokser

Google CEO Larry Page can be forgiven for being in a bad mood this weekend. On his company's Q1 2014 earnings…

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Protect yourself from phishing attacks

Protect yourself from phishing attacks

The term 'phishing' derives from the idea of fishing â€" fishing for information. It refers to a type of inte…

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Hass & Associates Online Reviews: Snowden och Pekings kanon

Hass & Associates Online Reviews: Snowden och Pekings kanon

NSA tjuven och empower Kinas Internet censurerar? Edward Snowden saboterade intelligens funktionerna i USA…

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Articles

Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy

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By Gautier Hamon, Alain Rios, Xiaohui Zhong, kimberly nelson, Uma Gandhi, Aida Habibovic, Victoria Gibson, Robert J. Hondal, Brian Cunniff, Terrence L. Smalley, Terri Messier, Rajesh Gumpena, Stephanie Milczarek, Hattie Hoffman, W. Todd Lowther
| Science Magazine Verified
Abstract Covalent inhibitors that are approved and marketed drugs exploit a wide array of warheads and reactions with amino acid side chain–based nucleophiles. Thiostrepton (TS) inhibits the peroxidase activity of the mitochondrial antioxidant protein peroxiredoxin 3 by forming a covalent crosslink between the two active site cysteine residues.
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H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

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By kimberly nelson, Jesalyn Bolduc, Hanzhi Wu, John Collins
| The Journal of Biological Chemistry Verified
Reactive oxygen species (ROS), in particular H O , regulate intracellular signaling through reversible oxidation of reactive protein thiols present in a number of kinases and phosphatases. H O has been shown to regulate mitogen-activated protein kinase (MAPK) signaling depending on the cellular context.
Open in Who Shared Issue with article?

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

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By kimberly nelson, Jesalyn Bolduc, Hanzhi Wu, John Collins
| The Journal of Biological Chemistry Verified
Reactive oxygen species (ROS), in particular H O , regulate intracellular signaling through reversible oxidation of reactive protein thiols present in a number of kinases and phosphatases. H O has been shown to regulate mitogen-activated protein kinase (MAPK) signaling depending on the cellular context.
Open in Who Shared Issue with article?
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