kimberly nelson

Abstract Covalent inhibitors that are approved and marketed drugs exploit a wide array of warheads and reactions with amino acid side chain–based nucleophiles. Thiostrepton (TS) inhibits the peroxidase activity of the mitochondrial antioxidant protein peroxiredoxin 3 by forming a covalent crosslink between the two active site cysteine residues.

Reactive oxygen species (ROS), in particular H O , regulate intracellular signaling through reversible oxidation of reactive protein thiols present in a number of kinases and phosphatases. H O has been shown to regulate mitogen-activated protein kinase (MAPK) signaling depending on the cellular context.

Reactive oxygen species (ROS), in particular H O , regulate intracellular signaling through reversible oxidation of reactive protein thiols present in a number of kinases and phosphatases. H O has been shown to regulate mitogen-activated protein kinase (MAPK) signaling depending on the cellular context.