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Kiven Kumar on Muck Rack

Kiven Kumar

As seen in: Nature, MDPI
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Articles

Nucleotide deletions in dengue virus 3’ untranslated region compromises protein translation of live attenuated dengue vaccine strains

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By Kiven Kumar, Justin SG Ooi, Kuan Rong Chan, Esteban Finol, Eng Eong Ooi, Charlene H. M. Leong
| Nature Verified
Abstract The live attenuated tetravalent dengue vaccine candidate, TV003 has now completed phase III clinical trial and is now licensed in Brazil. It is composed of DENV-1 and -4 that were attenuated through 30-nucleotide deletion (Δ30) in the 3’ untranslated region (3’UTR); the DENV-4 Δ30 backbone was also used to construct a chimeric virus bearing the pre-membrane and envelope genes of DENV-2. Attenuation of DENV-3 required an additional 31-nucleotide deletion (Δ30/31) in the 3’UTR.
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Virus-like Particles of Nodavirus Displaying the Receptor Binding Domain of SARS-CoV-2 Spike Protein: A Potential VLP-Based COVID-19 Vaccine

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By Kok Lian Ho, Kiven Kumar, Siti Suri Arshad, Wen Siang
| MDPI
Abstract : Since the outbreak of the coronavirus disease 2019 (COVID-19), various vaccines have been developed for emergency use. The efficacy of the initial vaccines based on the ancestral strain of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has become a point of contention due to the emergence of new variants of concern (VOCs).
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